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Reduced Odds of Mpox-Associated Hospitalization Among Persons Who Received JYNNEOS Vaccine — California, May 2022–May 2023

by Lo, Timothy , Ramos, Marisa , Keinde, Awa , Vance, Josh , Saadeh, Kayla , Peters, Philip , Watson, Jessica , Johnson, Kelly A. , Schildhauer, Samuel , Snyder, Robert , Jacobson, Kathleen , Quint, Joshua , Salih, Tarek , Tang, Eric C. , Gotlieb, Esther , Chapman, Eric , Chojolan, Edwin

in California - epidemiology / Effectiveness / Ethnicity / Full Report / HIV / HIV (Viruses) / HIV infection / HIV Infections - epidemiology / HIV Infections - prevention & control / HIV patients / Hospitalization / Human immunodeficiency virus / Humans / Immunity (Disease) / Immunization / Infection / Infections / Monkeypox virus / Mpox / Mpox (monkeypox) - epidemiology / Public health / Sexual orientation / Vaccines / Vaccines, Attenuated

2023

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Reduced Odds of Mpox-Associated Hospitalization Among Persons Who Received JYNNEOS Vaccine — California, May 2022–May 2023

2023

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Reduced Odds of Mpox-Associated Hospitalization Among Persons Who Received JYNNEOS Vaccine — California, May 2022–May 2023

2023

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Journal Article

Reduced Odds of Mpox-Associated Hospitalization Among Persons Who Received JYNNEOS Vaccine — California, May 2022–May 2023

Lo, Timothy,

Ramos, Marisa,

Keinde, Awa,

Vance, Josh,

Saadeh, Kayla,

Peters, Philip,

Watson, Jessica,

Johnson, Kelly A.,

Schildhauer, Samuel,

Snyder, Robert,

Jacobson, Kathleen,

Quint, Joshua,

Salih, Tarek,

Tang, Eric C.,

Gotlieb, Esther,

Chapman, Eric,

Chojolan, Edwin

2023

Overview

The effectiveness of 1 dose of JYNNEOS vaccine (modified vaccinia Ankara vaccine, Bavarian Nordic) against hospitalization for mpox (caused by Monkeypox virus), has been demonstrated; however, the impact of 2 doses on hospitalization risk, especially among persons infected with HIV, who are at higher risk for severe disease, is an important factor in evaluating vaccine effectiveness against mpox disease severity and Monkeypox virus infection. Surveillance data collected by the California Department of Public Health were used to evaluate whether receipt of 2 doses of JYNNEOS vaccine reduced the odds of hospitalization among persons with mpox. The odds of hospitalization among persons with mpox who had received 1 or 2 JYNNEOS doses were 0.27 (95% CI = 0.08-0.65) and 0.20 (95% CI = 0.01-0.90), respectively, compared with unvaccinated mpox patients. In mpox patients with HIV infection, the odds of hospitalization among those who had received 1 JYNNEOS vaccine dose was 0.28 (95% CI = 0.05-0.91) times that of those who were unvaccinated. No mpox-associated hospitalizations were identified among persons infected with HIV who had received 2 JYNNEOS vaccine doses. To optimize durable immunity, all eligible persons at risk for mpox, especially those infected with HIV, should complete the 2-dose JYNNEOS series.

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Publisher

U.S. Government Printing Office,U.S. Center for Disease Control,Centers for Disease Control and Prevention

Subject

California - epidemiology

/ HIV