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Occurrence and repair of alkylating stress in the intracellular pathogen Brucella abortus
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Occurrence and repair of alkylating stress in the intracellular pathogen Brucella abortus
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Journal Article
Occurrence and repair of alkylating stress in the intracellular pathogen Brucella abortus
2019
Overview
It is assumed that intracellular pathogenic bacteria have to cope with DNA alkylating stress within host cells. Here we use single-cell reporter systems to show that the pathogen
Brucella abortus
does encounter alkylating stress during the first hours of macrophage infection. Genes encoding direct repair and base-excision repair pathways are required by
B. abortus
to face this stress in vitro and in a mouse infection model. Among these genes,
ogt
is found to be under the control of the conserved cell-cycle transcription factor GcrA. Our results highlight that the control of DNA repair in
B. abortus
displays distinct features that are not present in model organisms such as
Escherichia coli
.
It is assumed that intracellular pathogenic bacteria must cope with DNA alkylating stress within host cells. Here, Poncin et al. show that the pathogen
Brucella abortus
does encounter alkylating stress within macrophages, and shed light into the pathways required for DNA repair in this organism.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 14/34
/ 14/35
/ 14/63
/ 42/70
/ 45/15
/ 45/88
/ 64/60
/ Animals
/ Brucella abortus - metabolism
/ Brucella abortus/genetics/metabolism
/ DNA
/ E coli
/ Genes
/ Host-Pathogen Interactions - genetics
/ Humanities and Social Sciences
/ Immunologie & maladie infectieuse
/ Immunology & infectious disease
/ Mice
/ Repair
/ Science
/ Sciences de la santé humaine
