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Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations
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Journal Article
Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations
2011
Overview
Dan Nicolae, Carole Ober and colleagues report a meta-analysis of genome-wide association studies for asthma in a collection of ethnically diverse North American populations. They identify a newly associated susceptibility locus at
PYHIN1
in individuals of African descent.
Asthma is a common disease with a complex risk architecture including both genetic and environmental factors. We performed a meta-analysis of North American genome-wide association studies of asthma in 5,416 individuals with asthma (cases) including individuals of European American, African American or African Caribbean, and Latino ancestry, with replication in an additional 12,649 individuals from the same ethnic groups. We identified five susceptibility loci. Four were at previously reported loci on 17q21, near
IL1RL1
,
TSLP
and
IL33
, but we report for the first time, to our knowledge, that these loci are associated with asthma risk in three ethnic groups. In addition, we identified a new asthma susceptibility locus at
PYHIN1
, with the association being specific to individuals of African descent (
P
= 3.9 × 10
−9
). These results suggest that some asthma susceptibility loci are robust to differences in ancestry when sufficiently large samples sizes are investigated, and that ancestry-specific associations also contribute to the complex genetic architecture of asthma.
Publisher
Nature Publishing Group US,Nature Publishing Group
Subject
/ Analysis
/ Animal Genetics and Genomics
/ Asthma
/ Biological and medical sciences
/ Biomedical and Life Sciences
/ Black or African American - genetics
/ Caribbean Region - ethnology
/ Chronic obstructive pulmonary disease, asthma
/ Fundamental and applied biological sciences. Psychology
/ Genetic Predisposition to Disease
/ Genetics of eukaryotes. Biological and molecular evolution
/ Genome-Wide Association Study
/ Genomes
/ Hispanic or Latino - genetics
/ Humans
/ letter
/ Risk
