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A bioinspired omniphobic surface coating on medical devices prevents thrombosis and biofouling
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A bioinspired omniphobic surface coating on medical devices prevents thrombosis and biofouling
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Journal Article
A bioinspired omniphobic surface coating on medical devices prevents thrombosis and biofouling
2014
Overview
A non-stick surface coating makes medical devices anti-thrombogenic and resistant to biofilm growth.
Thrombosis and biofouling of extracorporeal circuits and indwelling medical devices cause significant morbidity and mortality worldwide. We apply a bioinspired, omniphobic coating to tubing and catheters and show that it completely repels blood and suppresses biofilm formation. The coating is a covalently tethered, flexible molecular layer of perfluorocarbon, which holds a thin liquid film of medical-grade perfluorocarbon on the surface. This coating prevents fibrin attachment, reduces platelet adhesion and activation, suppresses biofilm formation and is stable under blood flow
in vitro
. Surface-coated medical-grade tubing and catheters, assembled into arteriovenous shunts and implanted in pigs, remain patent for at least 8 h without anticoagulation. This surface-coating technology could reduce the use of anticoagulants in patients and help to prevent thrombotic occlusion and biofouling of medical devices.
Publisher
Nature Publishing Group US,Nature Publishing Group
