Asset Details

MbrlCatalogueTitleDetail

Do you wish to reserve the book?

A multicentre validation study of the diagnostic value of plasma neurofilament light

by Santillo, Alexander , Bonanni, Laura , Rabinovici, Gil D. , Fernández-Eulate, Gorka , Al-Chalabi, Ammar , Novakova, Lenka , Hansson, Oskar , Pascoal, Tharick A. , Strydom, Andre , Stomrud, Erik , Thambisetty, Madhav , López de Munain, Adolfo , Resnick, Susan M. , Hye, Abdul , Lycke, Jan , Benedet, Andrea L. , Lleó, Alberto , Svenningsson, Per , Galimberti, Daniela , Axelsson, Markus , Schöll, Michael , Leuzy, Antoine , Janelidze, Shorena , Aarsland, Dag , Zetterberg, Henrik , van der Ende, Emma L. , Velayudhan, Latha , Gil-Bea, Francisco J. , Rosa-Neto, Pedro , Pariante, Carmine , Nikkheslat, Naghmeh , Padovani, Alessandro , Miller, Bruce , Palmqvist, Sebastian , Pilotto, Andrea , van Swieten, John C. , Parnetti, Lucilla , Blennow, Kaj , Karikari, Thomas K. , Ashton, Nicholas J. , Al Khleifat, Ahmad

in 631/378/1689/364 / 692/53/2421 / 692/53/2423 / Age / Age Factors / Aged / Amyotrophic lateral sclerosis / Basal ganglia / Basic Medicine / Biomarkers / Biomarkers - cerebrospinal fluid / Blood / Central nervous system diseases / Cerebrospinal fluid / Clinical Laboratory Medicine / Clinical Medicine / Cognitive ability / Cognitive Dysfunction - cerebrospinal fluid / Cognitive Dysfunction - diagnosis / Cohort Studies / Dementia / Dementia disorders / Depression - cerebrospinal fluid / Depression - diagnosis / Down syndrome / Down Syndrome - cerebrospinal fluid / Down Syndrome - diagnosis / Down's syndrome / False Positive Reactions / Female / Frontotemporal dementia / Humanities and Social Sciences / Humans / Klinisk laboratoriemedicin / Klinisk medicin / Male / Medical and Health Sciences / Medicin och hälsovetenskap / Medicinska och farmaceutiska grundvetenskaper / Mental disorders / Middle Aged / Movement disorders / multidisciplinary / Neurodegeneration / Neurodegenerative diseases / Neurodegenerative Diseases - cerebrospinal fluid / Neurodegenerative Diseases - diagnosis / Neurofilament Proteins - cerebrospinal fluid / Neurologi / Neurology / Neurosciences / Neurovetenskaper / Plasma / Predictive Value of Tests / Reference Values / Science / Science (multidisciplinary) / Sex Factors / Validation studies

2021

Yes Please

Hey, we have placed the reservation for you!

By the way, why not check out events that you can attend while you pick your title.

Oops! Something went wrong.

Looks like we were not able to place the reservation. Kindly try again later.

Are you sure you want to remove the book from the shelf?

A multicentre validation study of the diagnostic value of plasma neurofilament light

2021

Confirm

Do you wish to request the book?

A multicentre validation study of the diagnostic value of plasma neurofilament light

2021

Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy

How would you like to get it?

Submit

We have requested the book for you!

Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.

Oops! Something went wrong.

Looks like we were not able to place your request. Kindly try again later.

Journal Article

A multicentre validation study of the diagnostic value of plasma neurofilament light

Santillo, Alexander,

Bonanni, Laura,

Rabinovici, Gil D.,

Fernández-Eulate, Gorka,

Al-Chalabi, Ammar,

Novakova, Lenka,

Hansson, Oskar,

Pascoal, Tharick A.,

Strydom, Andre,

Stomrud, Erik,

Thambisetty, Madhav,

López de Munain, Adolfo,

Resnick, Susan M.,

Hye, Abdul,

Lycke, Jan,

Benedet, Andrea L.,

Lleó, Alberto,

Svenningsson, Per,

Galimberti, Daniela,

Axelsson, Markus,

Schöll, Michael,

Leuzy, Antoine,

Janelidze, Shorena,

Aarsland, Dag,

Zetterberg, Henrik,

van der Ende, Emma L.,

Velayudhan, Latha,

Gil-Bea, Francisco J.,

Rosa-Neto, Pedro,

Pariante, Carmine,

Nikkheslat, Naghmeh,

Padovani, Alessandro,

Miller, Bruce,

Palmqvist, Sebastian,

Pilotto, Andrea,

van Swieten, John C.,

Parnetti, Lucilla,

Blennow, Kaj,

Karikari, Thomas K.,

Ashton, Nicholas J.,

Al Khleifat, Ahmad

2021

Overview

Increased cerebrospinal fluid neurofilament light (NfL) is a recognized biomarker for neurodegeneration that can also be assessed in blood. Here, we investigate plasma NfL as a marker of neurodegeneration in 13 neurodegenerative disorders, Down syndrome, depression and cognitively unimpaired controls from two multicenter cohorts: King’s College London ( n = 805) and the Swedish BioFINDER study ( n = 1,464). Plasma NfL was significantly increased in all cortical neurodegenerative disorders, amyotrophic lateral sclerosis and atypical parkinsonian disorders. We demonstrate that plasma NfL is clinically useful in identifying atypical parkinsonian disorders in patients with parkinsonism, dementia in individuals with Down syndrome, dementia among psychiatric disorders, and frontotemporal dementia in patients with cognitive impairment. Data-driven cut-offs highlighted the fundamental importance of age-related clinical cut-offs for disorders with a younger age of onset. Finally, plasma NfL performs best when applied to indicate no underlying neurodegeneration, with low false positives, in all age-related cut-offs. Cerebrospinal fluid neurofilament light (NfL) is a biomarker for neurodegeneration that can also be assessed in blood. Here the authors show in a validation study the potential for plasma NfL as a biomarker for several neurodegenerative diseases.

Share this book

Add to My Shelf

Publisher

Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio

Subject

/ Age

/ Aged

/ Amyotrophic lateral sclerosis