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A chemical defence against phage infection
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A chemical defence against phage infection
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Journal Article
A chemical defence against phage infection
2018
Overview
The arms race between bacteria and the phages that infect them drives the continual evolution of diverse anti-phage defences. Previously described anti-phage systems have highly varied defence mechanisms
1
–
11
; however, all mechanisms rely on protein components to mediate defence. Here we report a chemical anti-phage defence system that is widespread in
Streptomyces
. We show that three naturally produced molecules that insert into DNA are able to block phage replication, whereas molecules that target DNA by other mechanisms do not. Because double-stranded DNA phages are the most numerous group in the biosphere and the production of secondary metabolites by bacteria is ubiquitous
12
, this mechanism of anti-phage defence probably has a major evolutionary role in shaping bacterial communities.
Streptomyces
secondary metabolites provide a chemical defence against phage predation.
