Asset Details
Do you wish to reserve the book?
Neurological and biological correlations of ODD with ADHD in children and adolescents: a systematic review
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Neurological and biological correlations of ODD with ADHD in children and adolescents: a systematic review
Do you wish to request the book?
Neurological and biological correlations of ODD with ADHD in children and adolescents: a systematic review
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Neurological and biological correlations of ODD with ADHD in children and adolescents: a systematic review
2026
Overview
Background
Attention Deficit Hyperactivity Disorder (ADHD) often coexists with Oppositional Defiant Disorder (ODD), exacerbating impairment. The distinct neurological and biological patterns that differentiate this comorbidity from ADHD alone remain unclear.
Method
We conducted systematic review of multi model correlates differentiating ODD+ADHD from ADHD alone following PRISMA 2020 with databases like MEDLINE, EMBASE, CINAHL, PsycINFO and Web of Sciences until August 2025. 144 full texts were reviewed and 26 studies were selected for final inclusion after 1457 records with 37 other sources. Designs included cross-sectional case-control studies, longitudinal studies, and imaging based on the ABCD framework, while measures covered structural and functional MRI, diffusion MRI, resting and task fNIRS, EEG and ERP, HPA-axis and immune-metabolic biomarkers, and executive and cognitive indices. The evaluation of bias employed RoB 2, ROBINS-I, and JBI, while synthesis utilised Braun-Clarke thematic analysis.
Results
Oppositionality involved limbic–striatal and cerebello-cortical differences, with ODD+ADHD showing greater executive and emotion-processing deficits than ADHD alone. ODD was linked to lower cortisol and reduced sympathetic reactivity, while ADHD showed higher cortisol and tryptophan–kynurenine shifts, with cytokines decreasing after methylphenidate.
Conclusion
ODD along with ADHD showed a distinct neurobiological and physiological pattern from ADHD alone. Such pattern is marked by greater executive and emotional regulation deficits with unique stress-response patterns, highlighting the need for tailored assessments and intervention approaches.
Publisher
BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
Subject
/ Amygdala
/ Antisocial personality disorder
/ Attention Deficit Disorder with Hyperactivity - diagnostic imaging
/ Attention Deficit Disorder with Hyperactivity - physiopathology
/ Attention deficit hyperactivity disorder
/ Behavior
/ Behavioral Science and Psychology
/ Child
/ Complications and side effects
/ Cortisol
/ Emotions
/ Hormones
/ Humans
/ ODD
/ Oppositional Defiant Disorder - diagnostic imaging
/ Oppositional Defiant Disorder - epidemiology
/ Oppositional Defiant Disorder - physiopathology
