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Association of clinical factors with survival outcomes in laryngeal squamous cell carcinoma (LSCC)
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Association of clinical factors with survival outcomes in laryngeal squamous cell carcinoma (LSCC)
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Association of clinical factors with survival outcomes in laryngeal squamous cell carcinoma (LSCC)
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Journal Article
Association of clinical factors with survival outcomes in laryngeal squamous cell carcinoma (LSCC)
2019
Overview
Treatment strategies in laryngeal squamous cell cancer (LSCC) straddle the need for long term survival and tumor control as well as preservation of laryngeal function as far as possible. We sought to identify prognostic factors affecting LSCC outcomes in our population.
Clinical characteristics, treatments and survival outcomes of patients with LSCC were analysed. Baseline comorbidity data was collected and age-adjusted Charlson Comorbidity Index (aCCI) was calculated. Outcomes of overall survival (OS), progression-free survival (PFS) and laryngectomy-free survival (LFS) were evaluated.
Two hundred and fifteen patients were included, 170 (79%) underwent primary radiation/ chemoradiation and the remainder upfront surgery with adjuvant therapy where indicated. The majority of patients were male, Chinese and current/ex-smokers. Presence of comorbidity was common with median aCCI of 3. Median OS was 5.8 years. On multivariable analyses, high aCCI and advanced nodal status were associated with inferior OS (HR 1.24 per one point increase in aCCI, P<0.001 and HR 3.52; p<0.001 respectively), inferior PFS (HR 1.14; p = 0.007 and HR 3.23; p<0.001 respectively) and poorer LFS (HR 1.19; p = 0.001 and HR 2.95; p<0.001 respectively). Higher tumor (T) stage was associated with inferior OS and LFS (HR 1.61; p = 0.02 and HR 1.91; p = 0.01 respectively).
In our Asian population, the presence of comorbidities and high nodal status were associated with inferior OS, PFS and LFS whilst high T stage was associated with inferior LFS and OS.
Publisher
Public Library of Science,Public Library of Science (PLoS)
Subject
/ Aged
/ Cancer
/ Chemoradiotherapy, Adjuvant - statistics & numerical data
/ Female
/ Humans
/ Laryngeal Neoplasms - mortality
/ Laryngeal Neoplasms - pathology
/ Laryngeal Neoplasms - therapy
/ Laryngectomy - statistics & numerical data
/ Larynx
/ Lymphatic Metastasis - pathology
/ Lymphatic Metastasis - therapy
/ Male
/ Medicine and Health Sciences
/ Neoadjuvant Therapy - statistics & numerical data
/ Oncology
/ Operating systems (Software)
/ Organ Sparing Treatments - statistics & numerical data
/ Patients
/ Smoking
/ Squamous Cell Carcinoma of Head and Neck - mortality
/ Squamous Cell Carcinoma of Head and Neck - pathology
/ Squamous Cell Carcinoma of Head and Neck - therapy
/ Studies
/ Surgery
/ Survival
/ Tumors
