Journal Article

Patients with Urinary Incontinence Appear More Likely to Develop Upper Urinary Tract Stones: A Nationwide, Population-Based Study with 8-Year Follow-Up

Chung, Hsiao-Jen, Lin, Chih-Chieh, Lin, Alex Tong-Long, Chen, Kuang-Kuo, Chen, Tzeng-Ji

2016

Overview

This study aimed to investigate associations between primary urinary incontinence and development of upper urinary tract stones in a nationwide population in Taiwan. Data of 1,777 adults with primary urinary incontinence and 26,655 controls (groups A, B, and C) without urinary incontinence at study inception were retrieved from the National Health Insurance System database in Taiwan and were analyzed retrospectively. No enrolled subjects had previous diagnosis of upper urinary tract stones or spinal cord injury. All subjects were followed through end of 2009, with a minimum follow-up of 8 years. A greater percentage of study subjects (334/1777, 18.8%) developed upper urinary tract stones than that of control groups A (865/8885, 9.7%) and B (888/8885, 10%), and C (930/8885, 10.5%) (all p-values < 0.0001). Urinary incontinence was associated with significantly increased risk of developing urinary tract stones (HR 1.99, 95% CI, 1.70-2.34, p < 0.001). Age and metabolic syndrome status were both associated with developing upper urinary tract stones (both p-values < 0.0001). After adjusting for metabolic syndrome, regression analysis showed that urinary incontinence was still associated with a significantly increased risk of developing upper urinary tract stones (HR 1.99, 95% CI = 1.76-2.26, p < 0.0001). Long-term follow-up of Taiwanese patients with primary urinary incontinence suggests that urinary incontinence is associated with a significantly increased risk of developing upper urinary tract stones. Study findings suggest that physicians treating patients with urinary incontinence should give attention to early detection of upper urinary tract stones.

• Publisher: Public Library of Science,Public Library of Science (PLoS)
• Subject: Adolescent / Adult / Adults / Age Factors / Aged / Aged, 80 and over / Alcohol / Biology and Life Sciences / Bladder / Complications and side effects / Data base management systems / Diabetes / Epidemiology / Female / Follow-Up Studies / Health insurance / Hospitals / Humans / Kidney stones / Male / Medical personnel / Medical research / Medicine / Medicine and Health Sciences / Mens health / Metabolic disorders / Metabolic syndrome / Metabolic Syndrome - complications / Middle Aged / Obesity / Patients / People and Places / Physicians / Population / Population studies / Population-based studies / Prevalence studies (Epidemiology) / Quality of life / Regression Analysis / Retrospective Studies / Risk Factors / Social Sciences / Spinal cord / Spinal cord injuries / Spinal cord injury / Taiwan - epidemiology / Urinary Calculi - epidemiology / Urinary Calculi - etiology / Urinary incontinence / Urinary Incontinence - complications / Urinary Incontinence - epidemiology / Urinary stones / Urinary tract / Urine / Urogenital system / Urology / Womens health / Young Adult