Journal Article

Effect of second-generation antipsychotics on cognition: current issues and future challenges

Bishop, Jeffrey R, Hill, S Kristian, Sweeney, John A., Palumbo, Donna

2010

Overview

Generalized cognitive impairments are stable deficits linked to schizophrenia and key factors associated with functional disability in the disorder. Preclinical data suggest that second-generation antipsychotics could potentially reduce cognitive impairments; however, recent large clinical trials indicate only modest cognitive benefits relative to first-generation antipsychotics. This might reflect a limited drug effect in humans, a differential drug effect due to brain alterations associated with schizophrenia, or limited sensitivity of the neuropsychological tests for evaluating cognitive outcomes. New adjunctive procognitive drugs may be needed to achieve robust cognitive and functional improvement. Drug discovery may benefit from greater utilization of translational neurocognitive biomarkers to bridge preclinical and clinical proof-of-concept studies, to optimize assay sensitivity, enhance cost efficiency, and speed progress in drug development.

• Publisher: Taylor & Francis,Expert Reviews Ltd,Informa Healthcare
• Subject: Animals / Antipsychotic Agents - classification / Antipsychotic Agents - therapeutic use / Antipsychotic drugs / antipsychotic medication / Antipsychotics / biomarker / biomarkers / Brain / Clinical trials / Cognition / Cognition - drug effects / Cognition Disorders - drug therapy / Cognition Disorders - etiology / Cognition Disorders - pathology / Cognitive ability / Data processing / Disease Models, Animal / Dosage and administration / Drug development / Drug discovery / Drug therapy / Drugs / Humans / Mental disorders / Neuroleptics / Neuropsychological Tests / neuropsychology / Randomized Controlled Trials as Topic / Reviews / Schizophrenia / Schizophrenia - complications / Translation