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Changes in Treatment Adherence and Glycemic Control During the Transition to Adolescence in Type 1 Diabetes
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Changes in Treatment Adherence and Glycemic Control During the Transition to Adolescence in Type 1 Diabetes
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Journal Article
Changes in Treatment Adherence and Glycemic Control During the Transition to Adolescence in Type 1 Diabetes
2012
Overview
OBJECTIVE: To test models of unidirectional and bidirectional change between treatment adherence and glycemic control in youth with type 1 diabetes. RESEARCH DESIGN AND METHODS: We conducted a 2-year longitudinal, multisite study of 225 youth with type 1 diabetes recruited at the cusp of adolescence (aged 9–11 years) to describe the mutual influences of glycemic control as measured by HbA1c and treatment adherence as measured by blood glucose monitoring frequency (BGMF) during the transition to adolescence. RESULTS: HbA1c increased from 8.2 to 8.6% (P < 0.001) and BGMF decreased from 4.9 to 4.5 checks per day (P < 0.02) during the 2-year period. Changes in the BGMF slope predicted changes in HbA1c. A change (increase) in HbA1c was associated with a change (decrease) in BGMF of 1.26 (P < 0.001) after controlling for covariates. CONCLUSIONS: The magnitude of the effect of declining treatment adherence (BGMF) on glycemic control in young adolescents may be even greater than declines observed among older adolescents. BGMF offers a powerful tool for targeted management of glycemic control for type 1 diabetes during the critical transition to adolescence.
Publisher
American Diabetes Association
Subject
/ Adolescent Behavior - psychology
/ Biological and medical sciences
/ blood
/ Blood Glucose Self-Monitoring
/ Child
/ Dextrose
/ Diabetes
/ Diabetes Mellitus, Type 1 - blood
/ Diabetes Mellitus, Type 1 - drug therapy
/ Diabetes Mellitus, Type 1 - psychology
/ Diabetes. Impaired glucose tolerance
/ Endocrine pancreas. Apud cells (diseases)
/ Etiopathogenesis. Screening. Investigations. Target tissue resistance
/ Female
/ Glucose
/ Glycated Hemoglobin A - metabolism
/ Humans
/ Hypoglycemia - prevention & control
/ Hypoglycemic Agents - therapeutic use
/ Insulin
/ insulin-dependent diabetes mellitus
/ Male
/ Medication Adherence - psychology
/ Medication Adherence - statistics & numerical data
/ Puberty
/ Public health. Hygiene-occupational medicine
/ Youth
