Journal Article

Genome-wide association study in Han Chinese identifies four new susceptibility loci for coronary artery disease

Wang, Qianqian, Pu, Xiaodong, Liu, Depei, Hu, Dongsheng, Hao, Yongchen, Shi, Yongyong, Dou, Chenlong, Ma, Yitong, Li, Xiangdong, Liu, Xuehui, He, Lin, Fang, Xianghua, Erdmann, Jeanette, Gu, C Charles, Wang, Ligui, Reilly, Muredach P, Chen, Runsheng, Yang, Ying, Chai, Guoping, Samani, Nilesh J, Schunkert, Heribert, Qiang, Boqin, Chen, Panpan, Zheng, Runping, Guo, Dongshuang, Kathiresan, Sekar, Zhao, Liancheng, Liu, Donghua, Wu, Xigui, Zhao, Qi, Liu, Fangchao, Yao, Cailiang, Li, Yun, Wang, Dong, Chen, Jingping, Ji, Jingfeng, Cheng, Jing, Tang, Yida, Huang, Jianfeng, Meng, Qingjie, Liu, Xiaoli, Li, Jianxin, Wu, Xianping, Ji, Xu, Chen, Shufeng, Li, Hongfan, Liu, Zhendong, Peng, Xiaozhong, Du, Zhenhan, Wang, Renping, Liang, Xiaohua, Lu, Fanghong, Yang, Xueli, Zhang, Liang, Wu, Naqiong, Lu, Xiangfeng, Wang, Mengqin, Yang, Jun, Yang, Yuejin, Duan, Xiufang, Ge, Dongliang, Yu, Lin, Chen, Lanying, Yu, Dahai, Sun, Dongling, Mo, Xingbo, Cao, Jie, Li, Ying, Mao, Qunxia, Zhou, Xiaoyang, Gu, Dongfeng, Wang, Laiyuan, Wu, Tangchun, Li, Dianjiang, Shen, Chong, Xu, Lihua, Fan, Zhongjie, Mu, Jianjun, Yang, Zili, Chen, Jichun

2012

Overview

Dongfeng Gu and colleagues report a genome-wide association study for coronary artery disease in Han Chinese individuals. They identify four loci newly associated with coronary artery disease. We performed a meta-analysis of 2 genome-wide association studies of coronary artery disease comprising 1,515 cases and 5,019 controls followed by replication studies in 15,460 cases and 11,472 controls, all of Chinese Han ancestry. We identify four new loci for coronary artery disease that reached the threshold of genome-wide significance ( P < 5 × 10 −8 ). These loci mapped in or near TTC32 - WDR35 , GUCY1A3 , C6orf10-BTNL2 and ATP2B1 . We also replicated four loci previously identified in European populations (in or near PHACTR1 , TCF21 , CDKN2A-CDKN2B and C12orf51 ). These findings provide new insights into pathways contributing to the susceptibility for coronary artery disease in the Chinese Han population.

• Publisher: Nature Publishing Group US,Nature Publishing Group
• Subject: 631/208/205/2138 / 631/208/727/2000 / 692/699/75/593/15 / 692/700/478/174 / Agriculture / Analysis / Animal Genetics and Genomics / Asian People - genetics / Atherosclerosis / Atherosclerosis (general aspects, experimental research) / Biological and medical sciences / Biomedical and Life Sciences / Biomedicine / Blood and lymphatic vessels / Blood pressure / Butyrophilins / Cancer Research / Cardiology. Vascular system / Cardiovascular disease / Case-Control Studies / China / Chromosome Mapping / Confidence intervals / Coronary Artery Disease - genetics / Coronary heart disease / Cytoskeletal Proteins / Disease susceptibility / Fundamental and applied biological sciences. Psychology / Gene Function / Genealogy / Genetic aspects / Genetic Predisposition to Disease / Genetics of eukaryotes. Biological and molecular evolution / Genome-Wide Association Study / Genomes / Guanylate Cyclase - genetics / Hedgehog Proteins / Human / Human Genetics / Humans / Hypertension / Independent sample / Intracellular Signaling Peptides and Proteins / letter / Linkage Disequilibrium / Medical sciences / Membrane Glycoproteins - genetics / Plasma Membrane Calcium-Transporting ATPases - genetics / Polymorphism, Single Nucleotide / Population genetics, reproduction patterns / Proteins - genetics / Receptors, Cytoplasmic and Nuclear - genetics / Risk factors / Single nucleotide polymorphisms / Soluble Guanylyl Cyclase / Studies / White People - genetics