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Mechanosensory hair cells express two molecularly distinct mechanotransduction channels
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Mechanosensory hair cells express two molecularly distinct mechanotransduction channels
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Journal Article
Mechanosensory hair cells express two molecularly distinct mechanotransduction channels
2017
Overview
Auditory hair cells contain mechanotransduction channels that are activated by sound. The authors show that Piezo2, a mechanotransduction channel important for touch perception, is expressed in auditory hair cells. Surprisingly, Piezo2 is not the mechanotransduction channel essential for auditory perception and is instead observed after damage to hair cells.
Auditory hair cells contain mechanotransduction channels that rapidly open in response to sound-induced vibrations. We report here that auditory hair cells contain two molecularly distinct mechanotransduction channels. One ion channel is activated by sound and is responsible for sensory transduction. This sensory transduction channel is expressed in hair cell stereocilia, and previous studies show that its activity is affected by mutations in the genes encoding the transmembrane proteins TMHS, TMIE, TMC1 and TMC2. We show here that the second ion channel is expressed at the apical surface of hair cells and that it contains the Piezo2 protein. The activity of the Piezo2-dependent channel is controlled by the intracellular Ca
2+
concentration and can be recorded following disruption of the sensory transduction machinery or more generally by disruption of the sensory epithelium. We thus conclude that hair cells express two molecularly and functionally distinct mechanotransduction channels with different subcellular distributions.
Publisher
Nature Publishing Group US,Nature Publishing Group
Subject
/ 13/51
/ 14/19
/ 14/63
/ 631/378
/ 64/110
/ 64/60
/ Analysis
/ Animal Genetics and Genomics
/ Animals
/ Cellular signal transduction
/ Hair
/ Hair cells (Sensory receptors)
/ Hair Cells, Auditory - cytology
/ Mechanotransduction, Cellular - genetics
/ Mechanotransduction, Cellular - physiology
/ Membrane Proteins - metabolism
/ Mutation
/ Proteins
