Asset Details
Do you wish to reserve the book?
Juvenile hormone regulation of Drosophila aging
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Juvenile hormone regulation of Drosophila aging
Do you wish to request the book?
Juvenile hormone regulation of Drosophila aging
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Juvenile hormone regulation of Drosophila aging
2013
Overview
Background
Juvenile hormone (JH) has been demonstrated to control adult lifespan in a number of non-model insects where surgical removal of the
corpora allata
eliminates the hormone’s source. In contrast, little is known about how juvenile hormone affects adult
Drosophila melanogaster
. Previous work suggests that insulin signaling may modulate Drosophila aging in part through its impact on juvenile hormone titer, but no data yet address whether reduction of juvenile hormone is sufficient to control Drosophila life span. Here we adapt a genetic approach to knock out the
corpora allata
in adult
Drosophila melanogaster
and characterize adult life history phenotypes produced by reduction of juvenile hormone. With this system we test potential explanations for how juvenile hormone modulates aging.
Results
A tissue specific driver inducing an inhibitor of a protein phosphatase was used to ablate the
corpora allata
while permitting normal development of adult flies.
Corpora allata
knockout adults had greatly reduced fecundity, inhibited oogenesis, impaired adult fat body development and extended lifespan. Treating these adults with the juvenile hormone analog methoprene restored all traits toward wildtype. Knockout females remained relatively long-lived even when crossed into a genotype that blocked all egg production. Dietary restriction further extended the lifespan of knockout females. In an analysis of expression profiles of knockout females in fertile and sterile backgrounds, about 100 genes changed in response to loss of juvenile hormone independent of reproductive state.
Conclusions
Reduced juvenile hormone alone is sufficient to extend the lifespan of
Drosophila melanogaster
. Reduced juvenile hormone limits reproduction by inhibiting the production of yolked eggs, and this may arise because juvenile hormone is required for the post-eclosion development of the vitellogenin-producing adult fat body. Our data do not support a mechanism for juvenile hormone control of longevity simply based on reducing the physiological costs of egg production. Nor does the longevity benefit appear to function through mechanisms by which dietary restriction extends longevity. We identify transcripts that change in response to juvenile hormone independent of reproductive state and suggest these represent somatically expressed genes that could modulate how juvenile hormone controls persistence and longevity.
Publisher
BioMed Central,BioMed Central Ltd,Springer Nature B.V
Subject
/ Animals
/ Biological products industry
/ Biomedical and Life Sciences
/ Corpora Allata - drug effects
/ Diet
/ Drosophila melanogaster - drug effects
/ Drosophila melanogaster - genetics
/ Drosophila melanogaster - growth & development
/ Eggs
/ Fat Body - growth & development
/ Female
/ Females
/ Genotype
/ Insects
/ Insulin
/ Juvenile Hormones - pharmacology
/ Male
/ Proteins
/ Stress, Physiological - drug effects
