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The DNA replication checkpoint aids survival of plants deficient in the novel replisome factor ETG1
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The DNA replication checkpoint aids survival of plants deficient in the novel replisome factor ETG1
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Journal Article
The DNA replication checkpoint aids survival of plants deficient in the novel replisome factor ETG1
2008
Overview
Complete and accurate chromosomal DNA replication is essential for the maintenance of the genetic integrity of all organisms. Errors in replication are buffered by the activation of DNA stress checkpoints; however, in plants, the relative importance of a coordinated induction of DNA repair and cell cycle‐arresting genes in the survival of replication mutants is unknown. In a systematic screen for
Arabidopsis thaliana
E2F target genes, the
E2F TARGET GENE 1
(
ETG1
) was identified as a novel evolutionarily conserved replisome factor. ETG1 was associated with the minichromosome maintenance complex and was crucial for efficient DNA replication. Plants lacking the
ETG1
gene had serrated leaves due to cell cycle inhibition triggered by the DNA replication checkpoints, as shown by the transcriptional induction of DNA stress checkpoint genes. The importance of checkpoint activation was highlighted by double mutant analysis: whereas
etg1
mutant plants developed relatively normally, a synthetically lethal interaction was observed between
etg1
and the checkpoint mutants
wee1
and
atr
, demonstrating that activation of a G2 cell cycle checkpoint accounts for survival of
ETG1
‐deficient plants.
Publisher
John Wiley & Sons, Ltd,Nature Publishing Group UK,Springer Nature B.V,Nature Publishing Group
