Journal Article

Impact of different visceral metastatic sites on survival in metastatic prostate cancer patients

Yang, Cheng-Kuang, Lin, Chia-Yen, Hung, Sheng-Chun, Wang, Shian-Shiang, Cheng, Jason Chia-Hsien, Li, Jian-Ri, Chiu, Kun-Yuan, Lai, Gu-Shun, Chen, Chuan-Shu

2024

Overview

Visceral metastasis is an important predictor for poor outcomes in prostate cancer, however, the prognostic significance surrounding the specific sites of visceral metastasis remains unclear. The aim of this study was to evaluate the impact of different visceral metastatic sites on survival in patients with prostate cancer. We identified patients with metastatic prostate cancer between January 1, 2010 and December 31, 2023 using the TriNetX database. Patients were divided into 4 cohorts according to their specific metastatic sites: lung metastases, brain metastases, liver metastases, and bone metastases. Survival analysis was calculated using the Kaplan-Meier method and Cox regression models. In total, 59,875 patients diagnosed with metastatic prostate cancer were identified, with 39,495 (65.2%) having bone metastases, 7,573 (12.5%) lung metastases, 5,240 (8.7%) brain metastases, and 7,567 (12.5%) liver metastases. The median overall survival was 44.4 months for patients with bone metastases, 31.9 months for lung metastases, 9.6 months for brain metastases, and 10 months for liver metastases. Lung metastases were associated with an improved survival when compared with liver and brain metastases. For patients with two visceral metastatic sites or concomitant bone metastases, liver metastases were related to worse outcomes. Asian patients experienced better OS than Caucasian and African American patients in visceral metastatic prostate cancer. Patients with lung metastases experienced better survival outcomes in prostate cancer with only one visceral metastatic site. Liver metastases were associated with worse outcomes when there were two visceral metastatic sites combined or concomitant bone metastases. Asian patients displayed improved survival rates when compared with both Caucasian and African American patients in visceral metastatic prostate cancer.

• Publisher: Public Library of Science,Public Library of Science (PLoS)
• Subject: Aged / Aged, 80 and over / Bone cancer / Bone Neoplasms - mortality / Bone Neoplasms - secondary / Brain / Brain cancer / Brain Neoplasms - mortality / Brain Neoplasms - secondary / Brain research / Care and treatment / Confidence intervals / Diagnosis / Humans / Kaplan-Meier Estimate / Liver / Liver cancer / Liver Neoplasms - mortality / Liver Neoplasms - secondary / Lung cancer / Lung Neoplasms - mortality / Lung Neoplasms - pathology / Lung Neoplasms - secondary / Lungs / Lymphatic system / Male / Medical diagnosis / Medical prognosis / Metastases / Metastasis / Middle Aged / Neoplasm Metastasis / Patients / Prognosis / Proportional Hazards Models / Prostate cancer / Prostatic Neoplasms - mortality / Prostatic Neoplasms - pathology / Regression analysis / Regression models / Risk factors / Survival / Survival analysis