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RNA-binding proteins in tumor progression
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Journal Article
RNA-binding proteins in tumor progression
2020
Overview
RNA-binding protein (RBP) has a highly dynamic spatiotemporal regulation process and important biological functions. They are critical to maintain the transcriptome through post-transcriptionally controlling the processing and transportation of RNA, including regulating RNA splicing, polyadenylation, mRNA stability, mRNA localization, and translation. Alteration of each process will affect the RNA life cycle, produce abnormal protein phenotypes, and thus lead to the occurrence and development of tumors. Here, we summarize RBPs involved in tumor progression and the underlying molecular mechanisms whereby they are regulated and exert their effects. This analysis is an important step towards the comprehensive characterization of post-transcriptional gene regulation involved in tumor progression.
Publisher
BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
Subject
/ Analysis
/ Antigens
/ Cancer
/ Chromatin Assembly and Disassembly
/ Gene Expression Regulation, Neoplastic
/ Genes
/ Genomes
/ Humans
/ Kinases
/ Medicine
/ Mutation
/ Neoplasm Proteins - physiology
/ Oncology
/ Protein Processing, Post-Translational
/ Proteins
/ Review
/ RNA Processing, Post-Transcriptional
/ RNA, Untranslated - metabolism
/ RNA-Binding Proteins - chemistry
/ RNA-Binding Proteins - physiology
/ Splicing
/ Subcellular Fractions - metabolism
/ Tumors
