Asset Details
Do you wish to reserve the book?
Quantifying Y chromosome loss in primary and metastatic prostate cancer by chromosome painting
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Quantifying Y chromosome loss in primary and metastatic prostate cancer by chromosome painting
Do you wish to request the book?
Quantifying Y chromosome loss in primary and metastatic prostate cancer by chromosome painting
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Quantifying Y chromosome loss in primary and metastatic prostate cancer by chromosome painting
2024
Overview
Somatic Y chromosome loss in hematopoietic cells is associated with higher mortality in men. However, the status of the Y chromosome in cancer tissue is not fully known due to technical limitations, such as difficulties in labelling and sequencing DNA from the Y chromosome. We have developed a system to quantify Y chromosome gain or loss in patient-derived prostate cancer organoids. Using our system, we observed Y chromosome loss in 4 of the 13 (31%) patient-derived metastatic castration-resistant prostate cancer (mCRPC) organoids; interestingly, loss of Yq (long arm of the Y chromosome) was seen in 38% of patient-derived organoids. Additionally, potential associations were observed between mCRPC and Y chromosome nullisomy. The prevalence of Y chromosome loss was similar in primary and metastatic tissue, suggesting that Y chromosome loss is an early event in prostate cancer evolution and may not a result of drug resistance or organoid derivation. This study reports quantification of Y chromosome loss and gain in primary and metastatic prostate cancer tissue and lays the groundwork for further studies investigating the clinical relevance of Y chromosome loss or gain in mCRPC.
Publisher
Public Library of Science,Public Library of Science (PLoS)
Subject
/ Analysis
/ Cancer
/ Chromosomes, Human, Y - genetics
/ Humans
/ Male
/ Medicine and Health Sciences
/ Neoplasm Metastasis - genetics
/ Prostatic Neoplasms - genetics
/ Prostatic Neoplasms - pathology
/ Prostatic Neoplasms, Castration-Resistant - genetics
/ Prostatic Neoplasms, Castration-Resistant - pathology
