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Single-cell atlas of early human brain development highlights heterogeneity of human neuroepithelial cells and early radial glia
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Single-cell atlas of early human brain development highlights heterogeneity of human neuroepithelial cells and early radial glia
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Journal Article
Single-cell atlas of early human brain development highlights heterogeneity of human neuroepithelial cells and early radial glia
2021
Overview
The human cortex comprises diverse cell types that emerge from an initially uniform neuroepithelium that gives rise to radial glia, the neural stem cells of the cortex. To characterize the earliest stages of human brain development, we performed single-cell RNA-sequencing across regions of the developing human brain, including the telencephalon, diencephalon, midbrain, hindbrain and cerebellum. We identify nine progenitor populations physically proximal to the telencephalon, suggesting more heterogeneity than previously described, including a highly prevalent mesenchymal-like population that disappears once neurogenesis begins. Comparison of human and mouse progenitor populations at corresponding stages identifies two progenitor clusters that are enriched in the early stages of human cortical development. We also find that organoid systems display low fidelity to neuroepithelial and early radial glia cell types, but improve as neurogenesis progresses. Overall, we provide a comprehensive molecular and spatial atlas of early stages of human brain and cortical development.
Eze et al. use single-cell sequencing and immunohistochemical validation to create an atlas of early human brain development. In the telencephalon, they discover a diversity of progenitor subtypes, including two that are enriched in humans.
Publisher
Nature Publishing Group US,Nature Publishing Group
Subject
/ 38/1
/ 38/32
/ 38/91
/ 45/100
/ 64
/ Animal Genetics and Genomics
/ Animals
/ Biomedical and Life Sciences
/ Brain
/ Cerebral Cortex - embryology
/ Ependymoglial Cells - cytology
/ Humans
/ Identification and classification
/ Neural Stem Cells - cytology
/ Neuroepithelial Cells - cytology
/ Neurons
/ Resource
