Journal Article

Evaluation of an onco-diet on body composition and inflammatory status of dogs with mammary tumor—Pilot study

Balieiro, Julio C. C., Fantoni, Denise T., Pontieri, Cristiana F. F., Brunetto, Marcio Antonio, Teixeira, Fabio A., Gonçales, Lucas A., Pfrimer, Karina, Massoco, Cristina de O., Porsani, Mariana Y. H., Bonder, Brana S. A., Nagashima, Julio K., de-Oliveira, Clair M.

2023

Overview

A high-protein hypercaloric diet enriched with glutamine and omega-3 polyunsaturated fatty acids was called an onco-diet. The goal was to verify the modulation of the inflammatory response and body composition of female dogs with mammary tumor after mastectomy, during onco-diet consumption, using a randomized, double-blinded, clinical trial. Six bitches (average age of 8.6 years) were allocated into Control Group—diet without glutamine, EPA and DHA supplementation; and six bitches (10.0 years) were allocated into Test—diet enriched with glutamine and omega-3. Serum measurements of TNF-α, IL-6, IL-10, IGF-1, C-reactive protein and determination of body composition were performed at pre- and post-surgical times. Statistical tests were used to compare the nutrient intake and dietary effects on inflammatory variables between the diets. No differences in concentrations of different cytokines (p>0.05) and C-reactive protein (CRP) (p = 0.51) were observed between the groups. The test group had a higher concentration of IGF-1 (p<0.05), higher percentage of muscle mass (p<0.01) and lower body fat (p<0.01), but the difference was present from initial and throughout the study. Onco-diet, enriched with glutamine and omega-3, in the amounts evaluated in this study, was not sufficient to modulate the inflammation and body composition of female dogs with mammary tumors submitted to unilateral mastectomy.

• Publisher: Public Library of Science,Public Library of Science (PLoS)
• Subject: Analysis / Animal sciences / Animals / Appetite / Biology and Life Sciences / Body composition / Body fat / Breast cancer / C-reactive protein / Cancer / Cytokines / Diet / Dietary intake / Dogs / Enrichment / Fatty acids / Females / Fish oils / Food / Food intake / Gene expression / Glutamine / Health aspects / High protein diet / Homeostasis / Immunology / Inflammation / Inflammatory response / Insulin-like growth factor I / Insulin-like growth factors / Interleukin 10 / Interleukin 6 / Mammary gland / Mastectomy / Medical prognosis / Medicine and Health Sciences / Metabolism / Metastasis / Nervous system / Physical Sciences / Polyunsaturated fatty acids / Proteins / Statistical analysis / Statistical tests / Tumor necrosis factor-TNF / Tumor necrosis factor-α / Tumors / Veterinary colleges / Veterinary medicine / Zoology