Asset Details
Do you wish to reserve the book?
High prevalence of anterior pituitary deficiencies after cranial radiation therapy for skull base meningiomas
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
High prevalence of anterior pituitary deficiencies after cranial radiation therapy for skull base meningiomas
Do you wish to request the book?
High prevalence of anterior pituitary deficiencies after cranial radiation therapy for skull base meningiomas
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
High prevalence of anterior pituitary deficiencies after cranial radiation therapy for skull base meningiomas
2021
Overview
Background
Cranial irradiation represents one of the first line treatment proposed in skull base meningiomas. While cranial irradiation is associated with a high risk of secondary hypopituitarism, few studies focused on the specific location of skull base meningiomas.
Methods
Fifty-two adults receiving photon-beam therapy for skull base meningiomas between 2003 and 2014 in our Institution were included. Anterior pituitary (ACTH, FSH, GH, LH, TSH and prolactin) as well as corresponding peripheral hormones (8 am-Cortisol, IGF-1, fT3, fT4, 17βestradiol or testosterone) were biologically screened before radiotherapy (baseline), then yearly until March 2019. The pituitary gland (PG) was delineated on CT and the mean dose delivered to it was calculated.
Results
Mean age at diagnosis was 56 +/− 14 years. Median follow-up was 7 years. Up to 60% of patients developed at least ≥2 pituitary deficiencies, 10 years after radiotherapy. Gonadotroph, thyrotroph, corticotroph and somatotroph deficiencies occurred in 37, 28, 18 and 15% of patients, respectively. Hyperprolactinemia was found in 13% of patients. None patient had only one pituitary deficiency. In the multivariate analysis, a delivered dose to the PG ≥ 50 Gy or a meningioma size ≥40 mm significantly increased the risk of developing hypopituitarism.
Conclusions
Over a long-term follow-up, cranial radiation therapy used in skull base meningiomas led to a high prevalence of hypopituitarism, further pronounced in case of tumor ≥4 cm. These results advocate for an annual and prolonged follow-up of the pituitary functions in patients with irradiated skull base meningiomas.
Publisher
BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
Subject
/ Adult
/ Aged
/ Biomedical and Life Sciences
/ Complications and side effects
/ Cranial Irradiation - adverse effects
/ Dose Fractionation, Radiation
/ Female
/ Follicle-stimulating hormone
/ Health Promotion and Disease Prevention
/ Humans
/ Hypopituitarism - epidemiology
/ Insulin-like growth factor I
/ Male
/ Meningeal Neoplasms - radiotherapy
/ Oncology
/ Patients
/ Pituitary Gland - radiation effects
/ Radiation Injuries - epidemiology
/ Radiation Injuries - etiology
/ Skull
/ Skull Base Neoplasms - radiotherapy
/ Surgery
/ Tumors
