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Methylomic profiling implicates cortical deregulation of ANK1 in Alzheimer's disease
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Methylomic profiling implicates cortical deregulation of ANK1 in Alzheimer's disease
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Journal Article
Methylomic profiling implicates cortical deregulation of ANK1 in Alzheimer's disease
2014
Overview
Alzheimer's disease (AD) is a chronic neurodegenerative disorder characterized by progressive neuropathology and cognitive decline. Here the authors describe an epigenome-wide association study (EWAS) of human post-mortem brain samples across multiple independent AD cohorts. They find consistent hypermethylation of the
ANK1
gene associated with neuropathology.
Alzheimer's disease (AD) is a chronic neurodegenerative disorder that is characterized by progressive neuropathology and cognitive decline. We performed a cross-tissue analysis of methylomic variation in AD using samples from four independent human post-mortem brain cohorts. We identified a differentially methylated region in the ankyrin 1 (
ANK1
) gene that was associated with neuropathology in the entorhinal cortex, a primary site of AD manifestation. This region was confirmed as being substantially hypermethylated in two other cortical regions (superior temporal gyrus and prefrontal cortex), but not in the cerebellum, a region largely protected from neurodegeneration in AD, or whole blood obtained pre-mortem from the same individuals. Neuropathology-associated
ANK1
hypermethylation was subsequently confirmed in cortical samples from three independent brain cohorts. This study represents, to the best of our knowledge, the first epigenome-wide association study of AD employing a sequential replication design across multiple tissues and highlights the power of this approach for identifying methylomic variation associated with complex disease.
Publisher
Nature Publishing Group US,Nature Publishing Group
Subject
/ 45/22
/ 45/61
/ 45/77
/ Aged
/ Alzheimer Disease - epidemiology
/ Alzheimer Disease - genetics
/ Alzheimer Disease - pathology
/ Animal Genetics and Genomics
/ Brain
/ Cerebral Cortex - physiology
/ Entorhinal Cortex - pathology
/ Entorhinal Cortex - physiology
/ Epigenesis, Genetic - genetics
/ Female
/ Genome-Wide Association Study
/ Humans
/ Male
/ Prefrontal Cortex - pathology
