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The duck genome and transcriptome provide insight into an avian influenza virus reservoir species

by Rao, Man , Herrero, Javier , Qian, Wubin , Bartschat, Sebastian , Sheng, Zheya , Zhao, Yaofeng , Kim, Heebal , Groenen, Martien a M , Li, Jianwen , Morisson, Mireille , Gan, Shangquan , Chen, Hualan , Burt, David W , Lee, Taeheon , Stadler, Peter F , Kraus, Robert H S , Kehr, Stephanie , Aldridge, Jerry R , Liu, Qiuyue , Cai, Qingle , Ren, Liming , Kaiser, Pete , Tafer, Hakim , Warren, Wesley C , Hu, Xiaoxiang , Vignal, Alain , Laboratoire de Génétique Cellulaire (LGC) , Wellcome Trust , Zhang, Yong , Fei, Jing , State Key Laboratory for Agrobiotechnology , Resource Ecology Group , Senckenberg Museum , Zhu, Pengyang , Goodman, Laurie , Du, Zhenlin , Fairley, Suan , Magor, Katharine E , Yi, Kang , Feng, Huapeng , Faraut, Thomas , Li, Ning , Zhao, Yiqiang , Pitel, Frederique , Huang, Yinhua , Webster, Robert G , Wang, Jun , Smith, Jacqueline , Li, Yingrui , Crooijmans, Richard P M A , Li, Bo , Griffin, Darren K , Kim, Kyu-Won , An, Yang , Searle, Steve , Marz, Manja

in 631/208/212 / a virus / Agriculture / Analysis / Anas platyrhynchos / Animal Genetics and Genomics / Animals / Aquatic birds / Avian influenza virus / Avian influenza viruses / Base Sequence / Biomedicine / Birds / Cancer Research / Chickens - genetics / Chromosomes / defensins / Disease Reservoirs / Disease Vectors / Ducks / Ducks - genetics / Ducks - immunology / Ducks - virology / duplication / expression / Female / Geese - genetics / Gene expression / gene family evolution / Gene Function / Genetic aspects / Genome - physiology / Genomes / Genomics / Health aspects / Host-Pathogen Interactions - genetics / Host-Pathogen Interactions - immunology / Human Genetics / Immunity - genetics / Influenza in Birds - genetics / Influenza in Birds - immunology / Life Sciences / maximum-likelihood / Molecular Sequence Data / phylogenetic trees / Phylogeny / positive selection / protein / Species Specificity / Taeniopygia guttata / Transcriptome - genetics / transmission / Viruses / Wildfowl / Zebra finch

2013

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The duck genome and transcriptome provide insight into an avian influenza virus reservoir species

2013

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2013

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Journal Article

The duck genome and transcriptome provide insight into an avian influenza virus reservoir species

Rao, Man,

Herrero, Javier,

Qian, Wubin,

Bartschat, Sebastian,

Sheng, Zheya,

Zhao, Yaofeng,

Kim, Heebal,

Groenen, Martien a M,

Li, Jianwen,

Morisson, Mireille,

Gan, Shangquan,

Chen, Hualan,

Burt, David W,

Lee, Taeheon,

Stadler, Peter F,

Kraus, Robert H S,

Kehr, Stephanie,

Aldridge, Jerry R,

Liu, Qiuyue,

Cai, Qingle,

Ren, Liming,

Kaiser, Pete,

Tafer, Hakim,

Warren, Wesley C,

Hu, Xiaoxiang,

Vignal, Alain,

Laboratoire de Génétique Cellulaire (LGC),

Wellcome Trust,

Zhang, Yong,

Fei, Jing,

State Key Laboratory for Agrobiotechnology,

Resource Ecology Group,

Senckenberg Museum,

Zhu, Pengyang,

Goodman, Laurie,

Du, Zhenlin,

Fairley, Suan,

Magor, Katharine E,

Yi, Kang,

Feng, Huapeng,

Faraut, Thomas,

Li, Ning,

Zhao, Yiqiang,

Pitel, Frederique,

Huang, Yinhua,

Webster, Robert G,

Wang, Jun,

Smith, Jacqueline,

Li, Yingrui,

Crooijmans, Richard P M A,

Li, Bo,

Griffin, Darren K,

Kim, Kyu-Won,

An, Yang,

Searle, Steve,

Marz, Manja

2013

Overview

The duck (Anas platyrhynchos) is one of the principal natural hosts of influenza A viruses. We present the duck genome sequence and perform deep transcriptome analyses to investigate immune-related genes. Our data indicate that the duck possesses a contractive immune gene repertoire, as in chicken and zebra finch, and this repertoire has been shaped through lineage-specific duplications. We identify genes that are responsive to influenza A viruses using the lung transcriptomes of control ducks and ones that were infected with either a highly pathogenic (A/duck/Hubei/49/05) or a weakly pathogenic (A/goose/Hubei/65/05) H5N1 virus. Further, we show how the duck's defense mechanisms against influenza infection have been optimized through the diversification of its β-defensin and butyrophilin-like repertoires. These analyses, in combination with the genomic and transcriptomic data, provide a resource for characterizing the interaction between host and influenza viruses.

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Publisher

Nature Publishing Group,CCSD,Nature Publishing Group US

Subject

/ a virus

/ Animal Genetics and Genomics

/ Animals