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Salmonella Pathogenicity Island 2-Dependent Evasion of the Phagocyte NADPH Oxidase
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Salmonella Pathogenicity Island 2-Dependent Evasion of the Phagocyte NADPH Oxidase
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Journal Article
Salmonella Pathogenicity Island 2-Dependent Evasion of the Phagocyte NADPH Oxidase
2000
Overview
A type III protein secretion system encoded by Salmonella pathogenicity island 2 (SPI2) has been found to be required for virulence and survival within macrophages. Here, SPI2 was shown to allow Salmonella typhimurium to avoid NADPH oxidase-dependent killing by macrophages. The ability of SPI2-mutant bacteria to survive in macrophages and to cause lethal infection in mice was restored by abrogation of the NADPH oxidase-dependent respiratory burst. Ultrastructural and immunofluorescence microscopy demonstrated efficient localization of the NADPH oxidase in the proximity of vacuoles containing SPI2-mutant but not wild-type bacteria, suggesting that SPI2 interferes with trafficking of oxidase-containing vesicles to the phagosome.
Publisher
American Society for the Advancement of Science,American Association for the Advancement of Science,The American Association for the Advancement of Science
Subject
/ Bacteria
/ Bacterial Proteins - genetics
/ Bacterial Proteins - physiology
/ Biological and medical sciences
/ Cerium
/ Chronic granulomatous disease
/ Fundamental and applied biological sciences. Psychology
/ Identification and classification
/ Macrophages, Peritoneal - enzymology
/ Macrophages, Peritoneal - microbiology
/ Macrophages, Peritoneal - ultrastructure
/ Mice
/ Oxidases
/ Proteins
/ Rodents
/ Salmonella Infections, Animal - microbiology
/ Salmonella typhimurium - genetics
/ Salmonella typhimurium - pathogenicity
/ Salmonella typhimurium - physiology
/ Tetradecanoylphorbol Acetate - pharmacology
/ Vacuoles
