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Maternal—Fetal rejection reactions are unconstrained in preeclamptic women
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Maternal—Fetal rejection reactions are unconstrained in preeclamptic women
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Journal Article
Maternal—Fetal rejection reactions are unconstrained in preeclamptic women
2017
Overview
The risk factors for preeclampsia, extremes of maternal age, changing paternity, concomitant maternal autoimmunity, and/or birth intervals greater than 5 years, suggest an underlying immunopathology. We used peripheral blood and lymphocytes from the UteroPlacental Interface (UPI) of 3rd trimester healthy pregnant women in multicolor flow cytometry-and in vitro suppression assays. The major end-point was the characterization of activation markers, and potential effector functions of different CD4-and CD8 subsets as well as T regulatory cells (Treg). We observed a significant shift of peripheral CD4 -and CD8- T cells from naïve to memory phenotype in preeclamptic women compared to healthy pregnant women consistent with long-standing immune activation. While the proportions of the highly suppressive Cytokine and Activated Treg were increased in preeclampsia, Treg tolerance toward fetal antigens was dysfunctional. Thus, our observations indicate a long-standing inflammatory derangement driving immune activation in preeclampsia; in how far the Treg dysfunction is caused by/causes this immune activation in preeclampsia will be the object of future studies.
Publisher
Public Library of Science,Public Library of Science (PLoS)
Subject
/ Adult
/ Antigens
/ Blood
/ CD8-Positive T-Lymphocytes - immunology
/ Cell Proliferation - drug effects
/ Complications and side effects
/ Female
/ Fetuses
/ Humans
/ Lymphocyte Activation - drug effects
/ Maternal-Fetal Exchange - drug effects
/ Maternal-Fetal Exchange - immunology
/ Medicine
/ Medicine and Health Sciences
/ Students
/ T-Lymphocytes, Regulatory - drug effects
