Journal Article

The values of coagulation function in COVID-19 patients

Gu, Junjuan, Chen, Yongfeng, Xie, Wen, Bao, Tengfei, Chen, Yawen, Li, Yuanyuan, Mao, Shi, Duan, Yongwei, Jin, Xin

2020

Overview

To investigate the blood coagulation function in COVID-19 patients, and the correlation between coagulopathy and disease severity. We retrospectively collected 147 clinically diagnosed COVID-19 patients at Wuhan Leishenshan Hospital of Hubei, China. We analyzed the coagulation function in COVID-19 patients through the data including thrombin-antithrombin complex (TAT), α2-plasmininhibitor-plasmin Complex (PIC), thrombomodulin (TM), t-PA/PAI-1 Complex (t-PAIC), prothrombin time (PT), international normalized ratio (INR), activated partial thromboplastin time (APTT), fibrinogen (FIB), thrombin time (TT), D-Dimer (DD), and platelet (PLT). The levels of TAT, PIC, TM, t-PAIC, PT, INR, FIB, and DD in COVID-19 patients were higher than health controls (p<0.05), and also higher in the patients with thrombotic disease than without thrombotic disease (p<0.05). What's more, the patients with thrombotic disease had a higher case-fatality (p<0.05). TAT, PIC, TM, t-PAIC, PT, INR, APTT, FIB, DD, and PLT were also found correlated with disease severity. Meanwhile, we found that there were significant difference in TAT, TM, t-PAIC, PT, INR, APTT, DD, and PLT in the death and survival group. Further using univariate and multivariate logistic regression analysis also found that t-PAIC and DD were independent risk factors for death in patients and are excellent predicting the mortality risk of COVID-19. Most COVID-19 patients with inordinate coagulation systems, dynamic monitoring of coagulation parameters might be a key in the control of COVID-19 death.

• Publisher: Public Library of Science,Public Library of Science (PLoS)
• Subject: Adult / Aged / Anticoagulants / Antithrombin / Betacoronavirus / Blood clots / Blood Coagulation / Blood Coagulation Disorders - virology / Blood Coagulation Tests / Care and treatment / Case-Control Studies / China / Coagulation / Coronavirus Infections - blood / Coronaviruses / COVID-19 / Death / Dimers / Fatalities / Female / Fibrinogen / Funding / Health aspects / Health risks / Heart failure / Hospitals / Humans / Laboratories / Male / Medical prognosis / Medicine / Middle Aged / Mortality / Mortality risk / Pandemics / Plasmin / Pneumonia / Pneumonia, Viral - blood / Prognosis / Prothrombin / Regression analysis / Respiratory diseases / Risk analysis / Risk factors / SARS-CoV-2 / Severe acute respiratory syndrome coronavirus 2 / Software / Statistical analysis / Thrombin / Thrombomodulin / Thromboplastin / Thrombosis