Journal Article

Combining viral genetic and animal mobility network data to unravel peste des petits ruminants transmission dynamics in West Africa

Kwiatek, Olivier, Niang, Mamadou, Apolloni, Andrea, Salami, Habib, Dakouo, Martin, Keyra, Mohamed, Doumbia, Baba, El Arbi, Ahmed, Salem, Sidibe, Cheick, Abou Kounta, Gueya, Mohamed, Baba, Barry, Yahya, Lo, Modou, Moustapha, Sidime, Youssouf, Habiboullah, Habiboullah, Sall, Baba, Direction des Services Vétérinaires de Dakar ; Ministère de l’Élevage et des Productions Animales [Dakar], Institut Supérieur des Sciences et de Médecine Vétérinaire de Dalaba (ISSMV/D), Lo, Mbargou, Seck, Ismaila, Département Systèmes Biologiques (Cirad-BIOS) ; Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad), Squarzoni Diaw, Cécile, Laboratoire National d'Elevage et de Recherches Vétérinaires [Dakar] (LNERV) ; Institut sénégalais de recherches agricoles [Dakar] (ISRA), El Mamy, Ahmed, Bezeid, Isselmou, Ekaterina, Coste, Caroline, Kaba, Lanceï, Ba, Aminata, Faye, Coumba, Ar. B., O.K., H.S. and G.L. were supported by a grant from the European Commission Animal Health and Welfare European Research Area Network (https://ec.eu

2021

Overview

Peste des petits ruminants (PPR) is a deadly viral disease that mainly affects small domestic ruminants. This disease threaten global food security and rural economy but its control is complicated notably because of extensive, poorly monitored animal movements in infected regions. Here we combined the largest PPR virus genetic and animal mobility network data ever collected in a single region to improve our understanding of PPR endemic transmission dynamics in West African countries. Phylogenetic analyses identified the presence of multiple PPRV genetic clades that may be considered as part of different transmission networks evolving in parallel in West Africa. A strong correlation was found between virus genetic distance and network-related distances. Viruses sampled within the same mobility communities are significantly more likely to belong to the same genetic clade. These results provide evidence for the importance of animal mobility in PPR transmission in the region. Some nodes of the network were associated with PPRV sequences belonging to different clades, representing potential \"hotspots\" for PPR circulation. Our results suggest that combining genetic and mobility network data could help identifying sites that are key for virus entrance and spread in specific areas. Such information could enhance our capacity to develop locally adapted control and surveillance strategies, using among other risk factors, information on animal mobility. As animals move so do viruses. The viral disease peste des petits ruminants (PPR) has a major impact on the livelihood of sheep and goat farmers across Africa, Middle-East and Asia. A global PPR eradication campaign is underway, but extensive movements of infected animals impede control efforts in many regions, such as West Africa. Here we show for the first time that PPR virus genetic data can be combined with information on animal mobility to identify routes of PPR circulation in Senegal and neighbouring countries. Such information can be used to design more efficient disease surveillance and control strategies adapted to local livestock farming practices.

• Publisher: CCSD,Public Library of Science,Public Library of Science (PLoS)
• Subject: Agricultural production / Agricultural sciences / Analysis / Animal production studies / Animals / Bayesian analysis / Biology and Life Sciences / Bluetongue / Clustering / Computer and Information Sciences / Conditional probability / Contagious caprine pleuropneumonia / Disease / Distribution / Gene sequencing / Genetic aspects / Genetic diversity / Genetic research / H gene / Life Sciences / Livestock / People and Places / Peste des petits ruminants / Phylogenetics / Phylogeny / Pleuropneumonia / Rinderpest / Shades / Signs and symptoms / Statistical inference / Surveillance / Viral genetics / Virus research / Viruses
• ISBN: 0006310277000