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Mechanisms and therapeutic potential of collateral sensitivity to antibiotics
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Journal Article
Mechanisms and therapeutic potential of collateral sensitivity to antibiotics
2021
Overview
Broken arrows indicate reduced functions. https://doi.org/10.1371/journal.ppat.1009172.g001 The first sensitivity mechanism to be understood is the generally 2- to 4-fold lower MIC of aminoglycoside-resistant E. coli to several classes of antibiotics (beta-lactams, fluoroquinolones, chloramphenicol, doxycycline, tetracycline) that is caused by mutations in the ion transport protein trkH [3]. [...]recent work provides an example for mechanism 4 [5]. Since CS has several potentially useful effects, e.g., (1) inhibition of growth with lower concentrations of antibiotic and (2) faster and stronger killing of a resistant bacterium (compared to the susceptible), it could be applied to both increasing efficacy and/or reducing the rate of resistance evolution. [...]in cases when the infection is caused by a bacterium that carries a resistance to another drug that increases susceptibility to any of these toxic antibiotics (which is expected be quite rare), a lower concentration could be used for treatment.
Publisher
Public Library of Science,Public Library of Science (PLoS)
Subject
/ Analysis
/ Anti-Bacterial Agents - pharmacology
/ Bacteria
/ Bacteria - growth & development
/ Complications and side effects
/ DNA
/ Drug resistance in microorganisms
/ Drug Resistance, Multiple, Bacterial - drug effects
/ E coli
/ Enzymes
/ Humans
/ Medicine and Health Sciences
/ Minimum inhibitory concentration
/ Mutation
/ Pearls
/ Plasmids
/ Proteins
