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Prognostic value of FoxP3 and CTLA-4 expression in patients with oral squamous cell carcinoma

by Nishiyama, Koyo , Tsuchihashi, Kei , Sasaya, Takashi , Hiratsuka, Hiroyoshi , Dehari, Hironari , Miyazaki, Akihiro , Torigoe, Toshihiko , Hasegawa, Tadashi , Sonoda, Tomoko , Sasaki, Takanori , Ogi, Kazuhiro , Shimizu, Shota , Koike, Kazushige

in Antibodies / Anticancer properties / Biology and Life Sciences / Cancer therapies / Cell survival / Chemotherapy / CTLA-4 protein / Foxp3 protein / Genetic aspects / Head & neck cancer / Health aspects / Immunoglobulins / Immunohistochemistry / Invasiveness / Lymphocytes / Lymphocytes T / Medical prognosis / Medicine / Medicine and Health Sciences / Metastases / Mouth cancer / Oral cancer / Oral squamous cell carcinoma / Parenchyma / Pathology / Patients / Prognosis / Radiation therapy / Software / Squamous cell carcinoma / Stroma / Supervision / Surgery / Survival / Transcription factors / Tumor-infiltrating lymphocytes / Tumors

2020

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Prognostic value of FoxP3 and CTLA-4 expression in patients with oral squamous cell carcinoma

2020

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Prognostic value of FoxP3 and CTLA-4 expression in patients with oral squamous cell carcinoma

2020

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Journal Article

Prognostic value of FoxP3 and CTLA-4 expression in patients with oral squamous cell carcinoma

Nishiyama, Koyo,

Tsuchihashi, Kei,

Sasaya, Takashi,

Hiratsuka, Hiroyoshi,

Dehari, Hironari,

Miyazaki, Akihiro,

Torigoe, Toshihiko,

Hasegawa, Tadashi,

Sonoda, Tomoko,

Sasaki, Takanori,

Ogi, Kazuhiro,

Shimizu, Shota,

Koike, Kazushige

2020

Overview

Tumor-infiltrating lymphocytes include tumor-reactive lymphocytes and regulatory T-cells. However, the prognostic value of tumor-infiltrating lymphocytes in oral squamous cell carcinoma (OSCC) remains unclear. We used immunohistochemistry to evaluate the presence of tumor-infiltrating FoxP3âº T-cells and CTLA-4âº cells in four distinct histological compartments (tumor parenchyma and stroma at the tumor center, and parenchyma and stroma at the invasive front) and assessed the association between the prevalence of these cells and the histopathological status of 137 patients with OSCC. Five-year overall survival, disease-specific survival, and recurrence-free survival were favorable in patients with high numbers of FoxP3âº T-cells in the parenchyma of the invasive front. Recurrence-free survival and metastasis-free survival were decreased in patients with high numbers of CTLA-4âº cells in the parenchyma of the invasive front. The presence of FoxP3âº T-cells in the parenchyma of the invasive front may be a useful prognostic factor. Our results indicate that FoxP3âº T-cells may exert site-specific anti-tumor effects but may not play an immunosuppressive role in OSCC. In addition, our results suggest that CTLA-4.sup.+ cells suppress the function of FoxP3.sup.+ T-cells and promote anti-tumor immunity in OSCC.

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Publisher

Public Library of Science,Public Library of Science (PLoS)

Subject

Antibodies

/ Anticancer properties

/ Biology and Life Sciences