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Fusobacterium nucleatum and oral cancer: a critical review
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Journal Article
Fusobacterium nucleatum and oral cancer: a critical review
2021
Overview
There is a growing level of interest in the potential role inflammation has on the initiation and progression of malignancy. Notable examples include
Helicobacter pylori
-mediated inflammation in gastric cancer and more recently
Fusobacterium nucleatum
-mediated inflammation in colorectal cancer.
Fusobacterium nucleatum
is a Gram-negative anaerobic bacterium that was first isolated from the oral cavity and identified as a periodontal pathogen. Biofilms on oral squamous cell carcinomas are enriched with anaerobic periodontal pathogens, including
F. nucleatum,
which has prompted hypotheses that this bacterium could contribute to oral cancer development. Recent studies have demonstrated that
F. nucleatum
can promote cancer by several mechanisms; activation of cell proliferation, promotion of cellular invasion, induction of chronic inflammation and immune evasion. This review provides an update on the association between
F. nucleatum
and oral carcinogenesis, and provides insights into the possible mechanisms underlying it.
Publisher
BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
Subject
/ Anti-Bacterial Agents - therapeutic use
/ Biofilms
/ Biomedical and Life Sciences
/ Colorectal Neoplasms - microbiology
/ Complications and side effects
/ Fusobacterium Infections - complications
/ Fusobacterium Infections - drug therapy
/ Fusobacterium nucleatum - immunology
/ Fusobacterium nucleatum - physiology
/ Gram-negative bacterial infections
/ Health Promotion and Disease Prevention
/ Humans
/ Metronidazole - therapeutic use
/ Mice
/ Mouth
/ Mouth Neoplasms - drug therapy
/ Mouth Neoplasms - microbiology
/ Oncology
/ Oral squamous cell carcinoma
/ OSCC
/ Review
/ Squamous Cell Carcinoma of Head and Neck - drug therapy
/ Squamous Cell Carcinoma of Head and Neck - microbiology
/ Tumors
