Journal Article

Effect of a high-protein, high-salt diet on calcium and bone metabolism in postmenopausal women stratified by hormone replacement therapy use

Bennett, T, Harrington, M, Flynn, A, Cashman, K.D, Oveson, L, Jakobsen, J, Brot, C

2004

Overview

The objective of this study was to investigate the influence of a high-sodium, high-protein diet on bone metabolism in postmenopausal women (aged 49-60 y) stratified by hormone replacement therapy (HRT) use. In a crossover trial, 18 women (n = 8 HRT users (+HRT) and n = 10 nonusers (-HRT)) were randomly assigned to a diet high in protein (90 g/day) and sodium (180 mmol/day) (calciuric diet) or a diet moderate in protein (70 g/day) and low in sodium (65 mmol/day) for 4 weeks followed by crossover to alternative dietary regimen for a further 4 weeks. The calciuric diet significantly (P < 0.05) increased urinary sodium, calcium and nitrogen in both groups. While the calciuric diet increased urinary N-telopeptide crosslinks of collagen (by approximately 25%, P = 0.003) in the -HRT group, it had no effect in the +HRT group. It appears that postmenopausal HRT use attenuates the increase in a marker of bone resorption associated with a calciuric diet.

• Publisher: Nature Publishing Group UK,Nature Publishing,Nature Publishing Group
• Subject: administration & dosage / Biological and medical sciences / biomarkers / blood / Bone and Bones / Bone and Bones - metabolism / Bone resorption / Bone turnover / Bones / Calcium / Calcium (urinary) / Calcium - blood / Calcium - metabolism / Calcium - urine / Calcium, Dietary / Calcium, Dietary - administration & dosage / Calcium, Dietary - metabolism / calciuric diet / Cholecalciferol / Cholecalciferol - blood / Clinical Nutrition / Collagen / Cross-linking / Cross-Over Studies / Diet / Dietary Proteins / Dietary Proteins - administration & dosage / Dose-Response Relationship, Drug / drug therapy / Epidemiology / excretion / Female / food intake / Gynecology. Andrology. Obstetrics / High protein diet / high sodium diet / hormonal regulation / Hormone Replacement Therapy / Humans / Internal Medicine / Medical sciences / Medicine / Medicine & Public Health / Menopause / Metabolic Diseases / Metabolism / Middle Aged / middle-aged adults / mineral metabolism / Nitrogen / Nitrogen - urine / Parathyroid Hormone / Parathyroid Hormone - blood / Post-menopause / postmenopausal women / Postmenopause / Protein turnover / Proteins / Puberal and climacteric disorders (male and female) / Public Health / Salt / short-communication / Sodium / sodium chloride / Sodium, Dietary / Sodium, Dietary - administration & dosage / Sodium, Dietary - blood / Sodium, Dietary - urine / urine / Women