Asset Details
Do you wish to reserve the book?
Genetic diversity of the African malaria vector Anopheles gambiae
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Genetic diversity of the African malaria vector Anopheles gambiae
Do you wish to request the book?
Genetic diversity of the African malaria vector Anopheles gambiae
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Genetic diversity of the African malaria vector Anopheles gambiae
2017
Overview
Genome sequencing analyses from 765 specimens of
Anopheles gambiae
and
Anopheles coluzzii
from 15 locations across Africa characterize patterns of gene flow and variations in population size, and provide a resource for studying the evolution of natural malaria vector populations.
Mosquito genetic diversity dataset
Anopheles gambiae
is the primary mosquito vector responsible for the transmission of malaria in most of sub-Saharan Africa. Alistair Miles, Dominic Kwiatkowski and colleagues report analyses from the
Anopheles gambiae
1000 Genomes Project (Ag1000G), including low-coverage genome sequences of 765 specimens of
Anopheles gambiae
and
Anopheles coluzzii
, caught in the wild at 15 locations across 8 countries in Africa. The authors analyse genetic variation, finding a high level of genetic diversity in these populations, and characterize patterns of gene flow and variations in population size. These datasets provide a resource for studies into the evolution of malaria vector populations that could guide control strategies and be used to address problems such as the evolution of insecticide resistance.
The sustainability of malaria control in Africa is threatened by the rise of insecticide resistance in
Anopheles
mosquitoes, which transmit the disease
1
. To gain a deeper understanding of how mosquito populations are evolving, here we sequenced the genomes of 765 specimens of
Anopheles gambiae
and
Anopheles coluzzii
sampled from 15 locations across Africa, and identified over 50 million single nucleotide polymorphisms within the accessible genome. These data revealed complex population structure and patterns of gene flow, with evidence of ancient expansions, recent bottlenecks, and local variation in effective population size. Strong signals of recent selection were observed in insecticide-resistance genes, with several sweeps spreading over large geographical distances and between species. The design of new tools for mosquito control using gene-drive systems will need to take account of high levels of genetic diversity in natural mosquito populations.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ Africa
/ Animals
/ Female
/ Genes
/ Genetic Variation - genetics
/ Genetics
/ Genomes
/ Genomics
/ Humanities and Social Sciences
/ Insecticide Resistance - genetics
/ letter
/ Malaria
/ Male
/ Polymorphism, Single Nucleotide - genetics
/ Principal components analysis
/ Science
