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Safety and immunogenicity of Ad26 and MVA vaccines in acutely treated HIV and effect on viral rebound after antiretroviral therapy interruption

by Intasan, Jintana , Thomas, Rasmi , Polonis, Victoria R. , Stieh, Daniel J. , Song, Hongshuo , Sarnecki, Michal , Kroon, Eugène , Paquin-Proulx, Dominic , Eller, Michael A. , Robb, Merlin L. , Tomaka, Frank L. , Vingerhoets, Johan , Schuitemaker, Hanneke , Shubin, Zhanna , Schuetz, Alexandra , Grandin, Pornsuk , Pinyakorn, Suteeraporn , Nkolola, Joseph P. , Truyers, Carla , Michael, Nelson , Kim, Dohoon , Pagliuzza, Amélie , Pau, Maria G. , Colby, Donn J. , Barouch, Dan H. , Sacdalan, Carlo , Phanuphak, Nittaya , Chomont, Nicolas , Wieczorek, Lindsay , Tovanabutra, Sodsai , Peter, Lauren , Tipsuk, Somporn , de Souza, Mark , Ananworanich, Jintanat

in 631/250/590 / 692/699/255/1901 / Acute Disease / Adolescent / Adult / AIDS vaccines / AIDS Vaccines - administration & dosage / AIDS Vaccines - adverse effects / AIDS Vaccines - immunology / Anti-Retroviral Agents - therapeutic use / Antigens / Antiretroviral agents / Antiretroviral drugs / Antiretroviral therapy / Antiviral agents / Biomedical and Life Sciences / Biomedicine / Brief Communication / Cancer Research / Clinical trials / Dosage and administration / Double-Blind Method / Drug Substitution - adverse effects / Drug therapy / Female / HIV / HIV infection / HIV Infections - immunology / HIV Infections - therapy / HIV Infections - virology / HIV-1 - drug effects / HIV-1 - immunology / Human immunodeficiency virus / Humans / Immune response / Immunogenicity / Immunogenicity, Vaccine - drug effects / Infectious Diseases / Male / Metabolic Diseases / Middle Aged / Molecular Medicine / Neurosciences / Patient outcomes / Placebos / Safety / Testing / Thailand / Treatment Outcome / Vaccines / Vaccinia / Viral Load - drug effects / Viral Vaccines - administration & dosage / Viral Vaccines - adverse effects / Viral Vaccines - immunology / Viruses / Withholding Treatment / Young Adult

2020

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Safety and immunogenicity of Ad26 and MVA vaccines in acutely treated HIV and effect on viral rebound after antiretroviral therapy interruption

2020

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Safety and immunogenicity of Ad26 and MVA vaccines in acutely treated HIV and effect on viral rebound after antiretroviral therapy interruption

2020

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Journal Article

Safety and immunogenicity of Ad26 and MVA vaccines in acutely treated HIV and effect on viral rebound after antiretroviral therapy interruption

Intasan, Jintana,

Thomas, Rasmi,

Polonis, Victoria R.,

Stieh, Daniel J.,

Song, Hongshuo,

Sarnecki, Michal,

Kroon, Eugène,

Paquin-Proulx, Dominic,

Eller, Michael A.,

Robb, Merlin L.,

Tomaka, Frank L.,

Vingerhoets, Johan,

Schuitemaker, Hanneke,

Shubin, Zhanna,

Schuetz, Alexandra,

Grandin, Pornsuk,

Pinyakorn, Suteeraporn,

Nkolola, Joseph P.,

Truyers, Carla,

Michael, Nelson,

Kim, Dohoon,

Pagliuzza, Amélie,

Pau, Maria G.,

Colby, Donn J.,

Barouch, Dan H.,

Sacdalan, Carlo,

Phanuphak, Nittaya,

Chomont, Nicolas,

Wieczorek, Lindsay,

Tovanabutra, Sodsai,

Peter, Lauren,

Tipsuk, Somporn,

de Souza, Mark,

Ananworanich, Jintanat

2020

Overview

We administered Ad26, modified vaccinia Ankara vectors containing mosaic HIV-1 antigens or placebo in 26 individuals who initiated antiretroviral therapy during acute human immunodeficiency virus infection as an exploratory study to determine the safety and duration of viremic control after treatment interruption. The vaccine was safe and generated robust immune responses, but delayed time to viral rebound compared to that in placebo recipients by only several days and did not lead to viremic control after treatment interruption (clinical trial NCT02919306). Test of therapeutic mosaic vaccines in HIV-infected individuals shows no control of virus after treatment interruption.

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Publisher

Nature Publishing Group US,Nature Publishing Group

Subject

/ Adult

/ AIDS Vaccines - administration & dosage