Journal Article

Using functional principal component analysis (FPCA) to quantify sitting patterns derived from wearable sensors

LaCroix, Andrea Z., Natarajan, Loki, Hartman, Sheri J., Zou, Jingjing, Rosenberg, Dori E., Carlson, Jordan A., Hibbing, Paul R., Di, Chongzhi, Dillon, Lindsay, Zablocki, Rong W., Greenwood-Hickman, Mikael Anne

2024

Overview

Background Sedentary behavior (SB) is a recognized risk factor for many chronic diseases. ActiGraph and activPAL are two commonly used wearable accelerometers in SB research. The former measures body movement and the latter measures body posture. The goal of the current study is to quantify the pattern and variation of movement (by ActiGraph activity counts) during activPAL-identified sitting events, and examine associations between patterns and health-related outcomes, such as systolic and diastolic blood pressure (SBP and DBP). Methods The current study included 314 overweight postmenopausal women, who were instructed to wear an activPAL (at thigh) and ActiGraph (at waist) simultaneously for 24 hours a day for a week under free-living conditions. ActiGraph and activPAL data were processed to obtain minute-level time-series outputs. Multilevel functional principal component analysis (MFPCA) was applied to minute-level ActiGraph activity counts within activPAL-identified sitting bouts to investigate variation in movement while sitting across subjects and days. The multilevel approach accounted for the nesting of days within subjects. Results At least 90% of the overall variation of activity counts was explained by two subject-level principal components (PC) and six day-level PCs, hence dramatically reducing the dimensions from the original minute-level scale. The first subject-level PC captured patterns of fluctuation in movement during sitting, whereas the second subject-level PC delineated variation in movement during different lengths of sitting bouts: shorter (< 30 minutes), medium (30 -39 minutes) or longer (> 39 minute). The first subject-level PC scores showed positive association with DBP (standardized β ^ : 2.041, standard error: 0.607, adjusted p = 0.007), which implied that lower activity counts (during sitting) were associated with higher DBP. Conclusion In this work we implemented MFPCA to identify variation in movement patterns during sitting bouts, and showed that these patterns were associated with cardiovascular health. Unlike existing methods, MFPCA does not require pre-specified cut-points to define activity intensity, and thus offers a novel powerful statistical tool to elucidate variation in SB patterns and health. Trial registration ClinicalTrials.gov NCT03473145; Registered 22 March 2018; https://clinicaltrials.gov/ct2/show/NCT03473145 ; International Registered Report Identifier (IRRID): DERR1-10.2196/28684

• Publisher: BioMed Central,BioMed Central Ltd,BMC
• Subject: Accelerometer / Accelerometry - instrumentation / Accelerometry - methods / actigraphy / Actigraphy - instrumentation / Actigraphy - methods / Aged / Behavioral Sciences / Biosensors / Blood Pressure - physiology / Chronic diseases / Clinical Nutrition / diastolic blood pressure / Exercise - physiology / Female / Functional Principal Component Analysis (FPCA) / Health aspects / Health Promotion and Disease Prevention / Humans / Medicine / Medicine & Public Health / Methods / Middle Aged / Movement / Multilevel FPCA / Overweight / Postmenopausal women / postmenopause / Postmenopause - physiology / posture / Principal Component Analysis / Principal components analysis / Risk factors / Sedentary Behavior / Sedentary Behavior (SB) / sedentary lifestyle / Sensors / Sitting Position / time series analysis / waist / Wearable Electronic Devices