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Progress toward treatments for synaptic defects in autism
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Journal Article
Progress toward treatments for synaptic defects in autism
2013
Overview
Autism spectrum disorders (ASDs) are a clinically heterogeneous group of neurodevelopmental disorders characterized by social and communication deficits and repetitive behaviors. In a subset of individuals with ASD, mutations in genes involved in synaptic function have been identified, and this Perspective discusses the evidence from mouse models of ASD that synaptic deficits can be ameliorated in the mature brain. The authors also suggest a strategy for designing more informative clinical trials for ASD therapies that stratify patients according to their specific synaptic mutations.
Autism spectrum disorder (ASD) encompasses a range of disorders that are characterized by social and communication deficits and repetitive behaviors. For the majority of affected individuals, the cause of ASD remains unknown, but in at least 20% of the cases, a genetic cause can be identified. There is currently no cure for ASD; however, results from mouse models indicate that some forms of the disorder could be alleviated even at the adult stage. Genes involved in ASD seem to converge on common pathways altering synaptic homeostasis. We propose, given the clinical heterogeneity of ASD, that specific 'synaptic clinical trials' should be designed and launched with the aim of establishing whether phenotype 'reversals' could also occur in humans.
Publisher
Nature Publishing Group US,Nature Publishing Group
Subject
/ Animals
/ Autism
/ Brain
/ Brain - growth & development
/ Child
/ Child Development Disorders, Pervasive
/ Child Development Disorders, Pervasive - genetics
/ Child Development Disorders, Pervasive - physiopathology
/ Child Development Disorders, Pervasive - therapy
/ Genetics
/ Humans
/ Mice
/ Pervasive developmental disorders
/ Synapses
