Journal Article

Derivation and validation of a new visceral adiposity index for predicting visceral obesity and cardiometabolic risk in a Korean population

Hye-Sun Lee, Sung-Kwan Oh, Ji-Won Lee, A-Ra Cho, Yu-Jin Kwon

2018

Overview

The visceral adiposity index (VAI), an indirect marker of visceral adipose tissue, serves as a model associated with cardiometabolic risk, but has limitations regarding the Asian population. We sought to develop a new VAI (NVAI) for the Korean population and compare it to VAI for prediction of atherosclerotic cardiovascular disease (ASCVD) risk and development of major cardiovascular diseases (CVD) and stroke. Patients (969) who underwent visceral fat area measurement were analyzed. After exclusion, 539 patients (142 men, 397 women) were randomly divided into internal (n = 374) and external validation (n = 165) data set. The NVAI was developed using univariate and multivariate logistic regression with backward selection of predictors. Receiver operating characteristic (ROC) curve analysis and comparison of the area under the curve (AUC) verified the better predictor of ASCVD risk score. Additionally, nationwide population-based cross-sectional survey data (Korean National Health and Nutrition Examination Survey [KNHANES] 2008-2010, n = 29,235) was used to validate the NVAI's ability to predict ASCVD risk and major CVD and stroke. The NVAI better reflected visceral fat area in internal and external data sets, with AUCs of 0.911 (95% confidence interval [CI]: 0.882-0.940) and 0.879 (95% CI: 0.828-0.931), respectively. NVAI better discriminated for ASCVD risk (AUC = 0.892, 95% CI: 0.846-0.938) compared to VAI (0.559, 95% CI: 0.439-0.679). The NVAI also better predicted MI or angina, and stroke with AUCs of 0.771 (95% CI: 0.752-0.789), and 0.812 (95% CI: 0.794-0.830), respectively, compared with waist circumference (WC), body mass index (BMI), TG to HDL ratio, and VAI via KNHANES, in a statistically significant manner. The NVAI has advantages as a predictor of visceral obesity and is significantly associated with ASCVD risks and development of major CVD and stroke in the Korean population. The NVAI could be a screening tool for improved risk estimation related to visceral obesity.

• Publisher: Public Library of Science (PLoS),Public Library of Science
• Subject: Abdomen / Adipose tissue / Adiposity / Adult / Aged / Angina / Area Under Curve / Arteriosclerosis / Atherosclerosis / Biology and Life Sciences / Blood pressure / Body mass / Body mass index / Body size / Cardiology / Cardiovascular disease / Cardiovascular Diseases / Cholesterol / Complications and side effects / Confidence intervals / Coronary vessels / Cross-Sectional Studies / Development and progression / Diabetes / Family medical history / Female / Health aspects / Health risks / Heart / High density lipoprotein / Hospitals / Humans / Hypertension / Insulin / Intra-Abdominal Fat / Male / Medical records / Medicine / Medicine and Health Sciences / Metabolic Diseases / Metabolic syndrome / Middle Aged / NMR / Nuclear magnetic resonance / Nutrition / Obesity / Obesity, Abdominal / Patients / Physical Sciences / Population / Predictions / Prognosis / Q / R / Regression analysis / Research and Analysis Methods / Research Article / Retrospective Studies / Risk / Risk Assessment / Risk factors / ROC Curve / Science / Statistical analysis / Stroke / Task forces / Tomography, X-Ray Computed / Womens health