Journal Article

Evaluation of Mood Disorder Questionnaire (MDQ) in Patients with Mood Disorders: A Multicenter Trial across China

Hu, Jian, Hu, Chen, Yuan, Cheng-Mei, Huang, Yi, Wang, Xiao-Ping, Li, Hui-Chun, Rong, Han, Chen, Zhi-Yu, Li, Ling-Jiang, Zhang, Jin-Bei, Liu, Tie-Bang, Ji, Er-Ni, Fang, Yi-Ru, Bi, Jian-Qiang, Sun, Jing, Peng, Hong-Jun, Yang, Hai-Chen, Si, Tian-Mei, Lu, Zheng

2014

Overview

The aim of this study was to test the ability of the Chinese version of the Mood Disorder Questionnaire (MDQ) to identify Bipolar Disorders (BD) in patients diagnosed with Major Depressive Disorder (MDD) or Unipolar Disorder (UD) in the clinical setting. 1,487 being treated for MDD or UD at 12 mental health centers across China, completed the MDQ and subsequently examined by the Mini International Neuropsychiatric Interview (MINI). Receiver Operating Characteristic(ROC) curves were used to determine the ability of the MDQ to differentiate between BD (BD, BD-I and BD-II) and MDD or UD and patients with BD-I from patients with BD-II. Of the 1,487 patients, 309 (20.8%) satisfied the DSM-IV criteria for BD: 118 (7.9%) for BD-I and 191 (12.8%) for BD-II. When only part one of the MDQ was used, the best cutoff was 7 between BD and UD (sensitivity 0.66, specificity 0.88, positive predictive value 0.59, negative predictive value 0.91), 6 between BD-II and UD, and 10 between BD-I and BD-II. If all three parts of the MDQ were used, the MDQ could not distinguish between BD and UD at a cutoff of 7 (or 6), and the sensitivity was only 0.22 (or 0.24). The Chinese version of the MDQ had good psychometric features in screening bipolar disorders from depressive patients with mood disorders when part two and part three of the MDQ were ignored.

• Publisher: Public Library of Science,Public Library of Science (PLoS)
• Subject: Adult / Affective disorders / Biology and Life Sciences / Bipolar disorder / Bipolar Disorder - diagnosis / Bipolar Disorder - epidemiology / Care and treatment / China - epidemiology / Depressive Disorder, Major - complications / Depressive Disorder, Major - diagnosis / Depressive Disorder, Major - epidemiology / Diagnosis / Disorders / Emotional disorders / Female / Health aspects / Hospitals / Humans / Male / Medical diagnosis / Medicine and Health Sciences / Mental depression / Mental disorders / Mental health / Mood / Mood Disorders - complications / Mood Disorders - diagnosis / Mood Disorders - epidemiology / Patients / Psychiatric Status Rating Scales / Psychiatry / Psychometrics - methods / Research and Analysis Methods / Sensitivity / Sensitivity and Specificity / Social Sciences / Studies / Surveys and Questionnaires / Validity