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Ciprofloxacin Enhances Stress Erythropoiesis in Spleen and Increases Survival after Whole-Body Irradiation Combined with Skin-Wound Trauma
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Ciprofloxacin Enhances Stress Erythropoiesis in Spleen and Increases Survival after Whole-Body Irradiation Combined with Skin-Wound Trauma
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Journal Article
Ciprofloxacin Enhances Stress Erythropoiesis in Spleen and Increases Survival after Whole-Body Irradiation Combined with Skin-Wound Trauma
2014
Overview
Severe hematopoietic loss is one of the major therapeutic targets after radiation-combined injury (CI), a kind of injury resulting from radiation exposure combined with other traumas. In this study, we tested the use of ciprofloxacin (CIP) as a treatment, because of recently reported immunomodulatory effects against CI that may improve hematopoiesis. The CIP regimen was a daily, oral dose for 3 weeks, with the first dose 2 h after CI. CIP treatment improved 30-day survival in mice at 80% compared to 35% for untreated controls. Study of early changes in hematological parameters identified CI-induced progressive anemia by 10 days that CIP significantly ameliorated. CI induced erythropoietin (EPO) mRNA in kidney and protein in kidney and serum; CIP stimulated EPO mRNA expression. In spleens of CI mice, CIP induced bone morphogenetic protein 4 (BMP4) in macrophages with EPO receptors. Splenocytes from CIP-treated CI mice formed CD71⁺ colony-forming unit-erythroid significantly better than those from controls. Thus, CIP-mediated BMP4-dependent stress erythropoiesis may play a role in improving survival after CI.
Publisher
Public Library of Science,Public Library of Science (PLoS)
Subject
/ Anemia - prevention & control
/ Animals
/ Biology
/ Blood
/ Bone morphogenetic protein 4
/ Bone Morphogenetic Protein 4 - metabolism
/ Ciprofloxacin - pharmacology
/ Disease
/ Erythropoiesis - drug effects
/ Female
/ Immunologic Factors - pharmacology
/ Kidneys
/ Medicine
/ Mice
/ Proteins
/ Radiation Injuries, Experimental - etiology
/ Radiation Injuries, Experimental - physiopathology
/ Reverse Transcriptase Polymerase Chain Reaction
/ RNA
/ Skin
/ Spleen
/ Stress, Physiological - drug effects
/ Stress, Physiological - radiation effects
/ Survival
/ Trauma
/ Whole-Body Irradiation - adverse effects
/ Wound Healing - drug effects
/ Wounds
