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In silico analysis of protein toxin and bacteriocins from Lactobacillus paracasei SD1 genome and available online databases
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In silico analysis of protein toxin and bacteriocins from Lactobacillus paracasei SD1 genome and available online databases
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Journal Article
In silico analysis of protein toxin and bacteriocins from Lactobacillus paracasei SD1 genome and available online databases
2017
Overview
Lactobacillus paracasei SD1 is a potential probiotic strain due to its ability to survive several conditions in human dental cavities. To ascertain its safety for human use, we therefore performed a comprehensive bioinformatics analysis and characterization of the bacterial protein toxins produced by this strain. We report the complete genome of Lactobacillus paracasei SD1 and its comparison to other Lactobacillus genomes. Additionally, we identify and analyze its protein toxins and antimicrobial proteins using reliable online database resources and establish its phylogenetic relationship with other bacterial genomes. Our investigation suggests that this strain is safe for human use and contains several bacteriocins that confer health benefits to the host. An in silico analysis of protein-protein interactions between the target bacteriocins and the microbial proteins gtfB and luxS of Streptococcus mutans was performed and is discussed here.
Publisher
Public Library of Science,Public Library of Science (PLoS)
Subject
/ Bacteria
/ Bacterial Toxins - metabolism
/ Biofilms
/ DNA
/ Genomes
/ Genomics
/ Internet
/ Lactobacillus paracasei - classification
/ Lactobacillus paracasei - drug effects
/ Lactobacillus paracasei - genetics
/ Lactobacillus paracasei - metabolism
/ Medicine and Health Sciences
/ Plasmids
/ Protein-protein interactions
/ Proteins
/ Research and Analysis Methods
/ RNA, Ribosomal, 16S - genetics
/ Science
/ Studies
/ Toxins
