Asset Details
Do you wish to reserve the book?
Fetal Alcohol Exposure and IQ at Age 8: Evidence from a Population-Based Birth-Cohort Study
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Fetal Alcohol Exposure and IQ at Age 8: Evidence from a Population-Based Birth-Cohort Study
Do you wish to request the book?
Fetal Alcohol Exposure and IQ at Age 8: Evidence from a Population-Based Birth-Cohort Study
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Fetal Alcohol Exposure and IQ at Age 8: Evidence from a Population-Based Birth-Cohort Study
2012
Overview
Observational studies have generated conflicting evidence on the effects of moderate maternal alcohol consumption during pregnancy on offspring cognition mainly reflecting problems of confounding. Among mothers who drink during pregnancy fetal alcohol exposure is influenced not only by mother's intake but also by genetic variants carried by both the mother and the fetus. Associations between children's cognitive function and both maternal and child genotype at these loci can shed light on the effects of maternal alcohol consumption on offspring cognitive development.
We used a large population based study of women recruited during pregnancy to determine whether genetic variants in alcohol metabolising genes in this cohort of women and their children were related to the child's cognitive score (measured by the Weschler Intelligence Scale) at age 8.
We found that four genetic variants in alcohol metabolising genes in 4167 children were strongly related to lower IQ at age 8, as was a risk allele score based on these 4 variants. This effect was only seen amongst the offspring of mothers who were moderate drinkers (1-6 units alcohol per week during pregnancy (per allele effect estimates were -1.80 (95% CI= -2.63 to -0.97) p=0.00002, with no effect among children whose mothers abstained during pregnancy (0.16 (95%CI= -1.05 to 1.36) p=0.80), p-value for interaction =0.009). A further genetic variant associated with alcohol metabolism in mothers was associated with their child's IQ, but again only among mothers who drank during pregnancy.
Publisher
Public Library of Science,Public Library of Science (PLoS)
Subject
/ Alcohol Dehydrogenase - genetics
/ Alcohols
/ Alleles
/ Analysis
/ Biology
/ Child
/ Children
/ Drinking (Alcoholic beverages)
/ Enzymes
/ Ethanol
/ Ethics
/ Exposure
/ Female
/ Genes
/ Genotype
/ Humans
/ Maternal-Fetal Exchange - physiology
/ Medicine
/ Prenatal Exposure Delayed Effects - epidemiology
/ Prenatal Exposure Delayed Effects - genetics
/ Prenatal Exposure Delayed Effects - physiopathology
/ Studies
