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Actinomadura graeca sp. nov.: A novel producer of the macrocyclic antibiotic zelkovamycin
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Actinomadura graeca sp. nov.: A novel producer of the macrocyclic antibiotic zelkovamycin
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Journal Article
Actinomadura graeca sp. nov.: A novel producer of the macrocyclic antibiotic zelkovamycin
2021
Overview
As part of a screening programme for antibiotic-producing bacteria, a novel Actinomadura species was discovered from a soil sample collected in Santorini, Greece. Preliminary 16S rRNA gene sequence comparisons highlighted Actinomadura macra as the most similar characterised species. However, whole-genome sequencing revealed an average nucleotide identity (ANI) value of 89% with A . macra , the highest among related species. Further phenotypic and chemotaxonomic analyses confirmed that the isolate represents a previously uncharacterised species in the genus Actinomadura , for which the name Actinomadura graeca sp. nov. is proposed (type strain 32-07 T ). The G+C content of A . graeca 32–07 is 72.36%. The cell wall contains DL-diaminopimelic acid, intracellular sugars are glucose, ribose and galactose, the predominant menaquinone is MK-9(H 6 ), the major cellular lipid is phosphatidylinositol and fatty acids consist mainly of hexadecanoic acid. No mycolic acid was detected. Furthermore, A . graeca 32–07 has been confirmed as a novel producer of the non-ribosomal peptide antibiotic zelkovamycin and we report herein a provisional description of the unique biosynthetic gene cluster.
Publisher
Public Library of Science,Public Library of Science (PLoS)
Subject
/ Actinomadura - ultrastructure
/ Analysis
/ Antimicrobial Cationic Peptides - biosynthesis
/ Antimicrobial Cationic Peptides - genetics
/ Computer and Information Sciences
/ DNA
/ Genomes
/ Glucose
/ Glycerol
/ Lipids
/ Macrocyclic Compounds - metabolism
/ Medicine and Health Sciences
/ Peptides
/ Pharmacy
/ Ribose
/ rRNA 16S
/ Scanning electron microscopy
/ Sugar
/ Yeast
