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ppk23-Dependent Chemosensory Functions Contribute to Courtship Behavior in Drosophila melanogaster
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ppk23-Dependent Chemosensory Functions Contribute to Courtship Behavior in Drosophila melanogaster
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ppk23-Dependent Chemosensory Functions Contribute to Courtship Behavior in Drosophila melanogaster
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Journal Article
ppk23-Dependent Chemosensory Functions Contribute to Courtship Behavior in Drosophila melanogaster
2012
Overview
Insects utilize diverse families of ion channels to respond to environmental cues and control mating, feeding, and the response to threats. Although degenerin/epithelial sodium channels (DEG/ENaC) represent one of the largest families of ion channels in Drosophila melanogaster, the physiological functions of these proteins are still poorly understood. We found that the DEG/ENaC channel ppk23 is expressed in a subpopulation of sexually dimorphic gustatory-like chemosensory bristles that are distinct from those expressing feeding-related gustatory receptors. Disrupting ppk23 or inhibiting activity of ppk23-expressing neurons did not alter gustatory responses. Instead, blocking ppk23-positive neurons or mutating the ppk23 gene delayed the initiation and reduced the intensity of male courtship. Furthermore, mutations in ppk23 altered the behavioral response of males to the female-specific aphrodisiac pheromone 7(Z), 11(Z)-Heptacosadiene. Together, these data indicate that ppk23 and the cells expressing it play an important role in the peripheral sensory system that determines sexual behavior in Drosophila.
Publisher
Public Library of Science,Public Library of Science (PLoS)
Subject
/ Animals
/ Animals, Genetically Modified
/ Biology
/ Drosophila melanogaster - genetics
/ Drosophila melanogaster - physiology
/ Drosophila Proteins - genetics
/ Drosophila Proteins - metabolism
/ Female
/ Insects
/ Male
/ Mutation
/ Proteins
/ Rodents
/ Sexual Behavior, Animal - drug effects
