Journal Article

Oral microbiota reveals signs of acculturation in Mexican American women

Ajami, Nadim J., Chow, Wong-Ho, Hoffman, Kristi L., Fowler, Jerry, Smith, Daniel P., Hutchinson, Diane S., Daniel, Carrie R., Zhao, Hua, Scheet, Paul, Petrosino, Joseph F.

2018

Overview

The oral microbiome has been linked to a number of chronic inflammatory conditions, including obesity, diabetes, periodontitis, and cancers of the stomach and liver. These conditions disproportionately affect Mexican American women, yet few studies have examined the oral microbiota in this at-risk group. We characterized the 16S rDNA oral microbiome in 369 non-smoking women enrolled in the MD Anderson Mano a Mano Mexican American Cohort Study. Lower bacterial diversity, a potential indicator of oral health, was associated with increased age and length of US residency among recent immigrants. Grouping women by overarching bacterial community type (e.g., \"Streptococcus,\" \"Fusobacterium,\" and \"Prevotella\" clusters), we observed differences across a number of acculturation-related variables, including nativity, age at immigration, time in the US, country of longest residence, and a multi-dimensional acculturation scale. Participants in the cluster typified by higher abundance of Streptococcus spp. exhibited the lowest bacterial diversity and appeared the most acculturated as compared to women in the \"Prevotella\" group. Computationally-predicted functional analysis suggested the Streptococcus-dominated bacterial community had greater potential for carbohydrate metabolism while biosynthesis of essential amino acids and nitrogen metabolism prevailed among the Prevotella-high group. Findings suggest immigration and adaption to life in the US, a well-established mediator of disease risk, is associated with differences in oral microbial profiles in Mexican American women. These results warrant further investigation into the joint and modifying effects of acculturation and oral bacteria on the health of Mexican American women and other immigrant populations. The oral microbiome presents an easily accessible biomarker of disease risk, spanning biological, behavioral, and environmental factors.

• Publisher: Public Library of Science,Public Library of Science (PLoS)
• Subject: Acculturation / Adult / Aged / Amino acids / Analysis / At risk populations / Bacteria / Bioindicators / Biological markers / Biology and Life Sciences / Biomarkers / Biosynthesis / Cancer / Carbohydrate metabolism / Carbohydrates / Chronic illnesses / Cohort analysis / Communities / Cultural factors / Diabetes / Diabetes mellitus / Disease / Disease prevention / Emigrants and Immigrants / Environmental aspects / Environmental factors / Epidemiology / Female / Functional analysis / Functionalism / Fusobacterium - isolation & purification / Genomes / Health risks / Hispanic Americans / Humans / Immigrants / Immigration / Inflammation / Liver / Medicine / Medicine and Health Sciences / Mental health / Metabolism / Mexican Americans / Microbiomes / Microbiota / Microbiota (Symbiotic organisms) / Microbiota - physiology / Microorganisms / Middle Aged / Mouth - microbiology / Nitrogen metabolism / Obesity / Oral hygiene / People and places / Periodontitis / Physiological aspects / Population / Prevotella - isolation & purification / Risk / Risk taking / rRNA 16S / Smoking / Stomach / Streptococcus - isolation & purification / Streptococcus infections / Virology / Women / Womens health / Young Adult