Asset Details
Do you wish to reserve the book?
Uncoordinated maturation of developing and regenerating postnatal mammalian vestibular hair cells
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Uncoordinated maturation of developing and regenerating postnatal mammalian vestibular hair cells
Do you wish to request the book?
Uncoordinated maturation of developing and regenerating postnatal mammalian vestibular hair cells
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Uncoordinated maturation of developing and regenerating postnatal mammalian vestibular hair cells
2019
Overview
Sensory hair cells are mechanoreceptors required for hearing and balance functions. From embryonic development, hair cells acquire apical stereociliary bundles for mechanosensation, basolateral ion channels that shape receptor potential, and synaptic contacts for conveying information centrally. These key maturation steps are sequential and presumed coupled; however, whether hair cells emerging postnatally mature similarly is unknown. Here, we show that in vivo postnatally generated and regenerated hair cells in the utricle, a vestibular organ detecting linear acceleration, acquired some mature somatic features but hair bundles appeared nonfunctional and short. The utricle consists of two hair cell subtypes with distinct morphological, electrophysiological and synaptic features. In both the undamaged and damaged utricle, fate-mapping and electrophysiology experiments showed that Plp1+ supporting cells took on type II hair cell properties based on molecular markers, basolateral conductances and synaptic properties yet stereociliary bundles were absent, or small and nonfunctional. By contrast, Lgr5+ supporting cells regenerated hair cells with type I and II properties, representing a distinct hair cell precursor subtype. Lastly, direct physiological measurements showed that utricular function abolished by damage was partially regained during regeneration. Together, our data reveal a previously unrecognized aberrant maturation program for hair cells generated and regenerated postnatally and may have broad implications for inner ear regenerative therapies.
Publisher
Public Library of Science,Public Library of Science (PLoS)
Subject
/ Animals
/ Balance
/ Bundles
/ Bundling
/ Cell Differentiation - physiology
/ Electrophysiological Phenomena - physiology
/ Funding
/ Hair
/ Hair cells (Mechanoreceptors)
/ Hair Cells, Auditory - cytology
/ Hair Cells, Auditory - physiology
/ Hair Cells, Vestibular - cytology
/ Hair Cells, Vestibular - physiology
/ Mammals
/ Mapping
/ Mechanoreceptors - physiology
/ Medicine
/ Medicine and Health Sciences
/ Saccule and Utricle - cytology
/ Saccule and Utricle - physiology
/ Surgery
/ Synaptic Transmission - physiology
/ Utricle
