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The emerging role of biosynthetic gene clusters in plant defense and plant interactions
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The emerging role of biosynthetic gene clusters in plant defense and plant interactions
The emerging role of biosynthetic gene clusters in plant defense and plant interactions
Journal Article

The emerging role of biosynthetic gene clusters in plant defense and plant interactions

2021
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Overview
Interestingly, pairing of protein functionality in plant defense can also occur in the form of fusion of functional domains within a single protein; nucleotide-binding leucine-rich repeat (NLR) proteins, involved in pathogen recognition, can be fused with various protein domains that serve as baits for pathogen effectors [12]. The specialized metabolites encoded by these BGCs have diverse modes of action, for example, disrupting pathogen cell membranes [16], conferring bitterness or toxicity that deters herbivores [17,18], undergoing pathogen-induced degradation to give bioactive volatiles [19], or forming physical barriers against biotic and abiotic stress factors [20]. [...]benzoxazinoids (defense compounds produced by grasses and some eudicots) have been implicated in regulation of defense responses, flowering time, auxin metabolism, and iron uptake in maize [32]; cyanogenic glycosides serve as nitrogen storage compounds in the rubber tree [33]; and perturbation of the pathway for the oat defense compound avenacin A-1 can result in accumulation of the precursor β-amyrin with associated effects on root epidermal cell patterning [34]. Genomic factors that may contribute to the formation, regulation, and evolution of BGCs include transposable element-mediated recombination [37], chromosomal inversion [38], gene shuffling [39,40], whole genome duplications [41,42], copy number variations of genes within BGCs [43], chromatin modification [44,45], and chromosomal 3D structure [46].