Journal Article

Depression and physical multimorbidity: A cohort study of physical health condition accrual in UK Biobank

Fleetwood, Kelly J., Jackson, Caroline A., Norrie, John D., Kelly, Paul A. T., Morales, Daniel R., Prigge, Regina, Guthrie, Bruce, Sudlow, Cathie, Mercer, Stewart W., Smith, Daniel J.

2025

Overview

Depression is associated with a range of adverse physical health outcomes. We aimed to quantify the association between depression and the subsequent rate of accrual of long-term physical health conditions in middle and older age. We included 172,556 participants from the UK Biobank (UKB) cohort study, aged 40-71 years old at baseline assessment (2006-2010), who had linked primary care data available. Using self-report, primary care, hospital admission, cancer registry, and death records, we ascertained 69 long-term physical health conditions at both UKB baseline assessment and during a mean follow-up of 6.9 years. We used quasi-Poisson models to estimate associations between history of depression at baseline and subsequent rate of physical condition accrual. Within our cohort, 30,770 (17.8%) had a history of depression. Compared to those without depression, participants with depression had more physical conditions at baseline (mean 2.9 [SD 2.3] versus 2.1 [SD 1.9]) and accrued additional physical conditions at a faster rate (mean 0.20 versus 0.16 additional conditions/year during follow-up). After adjustment for age and sex, participants with depression accrued physical morbidities at a faster rate than those without depression (RR 1.32, 95% confidence interval [CI] [1.31, 1.34]). After adjustment for all sociodemographic characteristics, the rate of condition accrual remained higher in those with versus without depression (RR 1.30, 95% CI [1.28, 1.32]). This association attenuated but remained statistically significant after additional adjustment for baseline condition count and social/lifestyle factors (RR 1.10, 95% CI [1.09, 1.12]). The main limitation of this study is healthy volunteer selection bias, which may limit generalisability of findings to the wider population. Middle-aged and older adults with a history of depression have more long-term physical health conditions at baseline and accrue additional physical conditions at a faster rate than those without a history of depression. Our findings highlight the importance of integrated approaches to managing both mental and physical health outcomes.

• Publisher: Public Library of Science,Public Library of Science (PLoS)
• Subject: Adult / Adults / Aged / Analysis / Biobanks / Biological Specimen Banks / Cancer / Care and treatment / Codes / Cohort analysis / Cohort Studies / Comorbidity / Demographic aspects / Depression - epidemiology / Depression, Mental / Diabetes / Diagnosis / Electronic health records / Female / Health Status / Hospitals / Humans / Male / Medical research / Medicine and Health Sciences / Mental depression / Middle age / Middle Aged / Multimorbidity / Older people / People and places / Prevalence studies (Epidemiology) / Primary care / Statistical analysis / UK Biobank / United Kingdom - epidemiology