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Direct Role for Dual Oxidase in Drosophila Gut Immunity
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Direct Role for Dual Oxidase in Drosophila Gut Immunity
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Journal Article
Direct Role for Dual Oxidase in Drosophila Gut Immunity
2005
Overview
Because the mucosal epithelia are in constant contact with large numbers of microorganisms, these surfaces must be armed with efficient microbial control systems. Here, we show that the Drosophila nicotinamide adenine dinucleotide phosphate (NADPH) oxidase enzyme, dual oxidase (dDuox), is indispensable for gut antimicrobial activities. Adult flies in which dDuox expression is silenced showed a marked increase in mortality rate even after a minor infection through ingestion of microbe-contaminated food. This could be restored by the specific reintroduction of dDuox, demonstrating that this oxidase generates a unique epithelial oxidative burst that limits microbial proliferation in the gut. Thus, oxidant-mediated antimicrobial responses are not restricted to the phagocytes, but rather are used more broadly, including in mucosal barrier epithelia.
Publisher
American Association for the Advancement of Science,The American Association for the Advancement of Science
Subject
/ Animals, Genetically Modified
/ Attrition (Research Studies)
/ Bacteria - growth & development
/ Biochemistry. Physiology. Immunology
/ Biological and medical sciences
/ Digestive System - enzymology
/ Digestive System - immunology
/ Digestive System - microbiology
/ Enzymes
/ foods
/ Fundamental and applied biological sciences. Psychology
/ Immunity
/ Insecta
/ Insects
/ Intestinal Mucosa - enzymology
/ Intestinal Mucosa - immunology
/ Intestinal Mucosa - microbiology
/ Oxidases
/ Reactive Oxygen Species - metabolism
/ Saccharomyces cerevisiae - growth & development
