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Resolving Difficult Phylogenetic Questions: Why More Sequences Are Not Enough
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Resolving Difficult Phylogenetic Questions: Why More Sequences Are Not Enough
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Journal Article
Resolving Difficult Phylogenetic Questions: Why More Sequences Are Not Enough
2011
Overview
According to the phylogenies of Schierwater et al. [...]the existence of horizontal transmission (e.g., hybridization of closely related taxa, organelle acquisition through endosymbiosis and horizontal gene transfer) makes phylogenetic trees only pragmatic approximations, which will probably be replaced by phylogenetic networks in the long term (particularly for unicellular organisms). Model of sequence evolution: A statistical description of the process of substitution in nucleotide or amino acid sequences.\\n Consequently, we stress the necessity of reducing its impact. Since taxon and gene sampling is being rapidly improved by the relentless progress in sequencing technology (even if obtaining well preserved and correctly identified specimens remains the limiting factor for several key taxa), full achievement of the ultimate goal of phylogenomics--i.e., accurate resolution of the Tree of Life--will primarily hinge on better procedures for the selection of orthologous and least saturated genes as well as on improved models of sequence evolution.
Publisher
Public Library of Science,Public Library of Science (PLoS)
Subject
/ Animals
/ Biochemistry, biophysics & molecular biology
/ Biochemistry, Molecular Biology
/ Biochimie, biophysique & biologie moléculaire
/ Computational Biology/Comparative Sequence Analysis
/ Evolutionary Biology/Bioinformatics
/ Evolutionary Biology/Genomics
/ Genetics & genetic processes
/ Genetics and Genomics/Bioinformatics
/ Genomes
/ Génétique & processus génétiques
/ Taxonomy
/ Trees
/ Zoologie
/ Zoology
