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Inhibition of Ubiquitin-specific Peptidase 8 Suppresses Adrenocorticotropic Hormone Production and Tumorous Corticotroph Cell Growth in AtT20 Cells
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Inhibition of Ubiquitin-specific Peptidase 8 Suppresses Adrenocorticotropic Hormone Production and Tumorous Corticotroph Cell Growth in AtT20 Cells
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Inhibition of Ubiquitin-specific Peptidase 8 Suppresses Adrenocorticotropic Hormone Production and Tumorous Corticotroph Cell Growth in AtT20 Cells
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Journal Article
Inhibition of Ubiquitin-specific Peptidase 8 Suppresses Adrenocorticotropic Hormone Production and Tumorous Corticotroph Cell Growth in AtT20 Cells
2016
Overview
Background： Two recent whole-exome sequencing researches identifying somatic mutations in the ubiquitin-specific protease 8 （USP8） gene in pituitary corticotroph adenomas provide exciting advances in this field. These mutations drive increased epidermal growth factor receptor （EGFR） signaling and promote adrenocorticotropic hormone （ACTH） production. This study was to investigate whether the inhibition of USP8 activity could be a strategy/br the treatment of Cushing＇s disease （CD）. Methods： The anticancer effect of USP8 inhibitor was determined by testing cell viability, colony tbrmation, apoptosis, and ACTH secretion. The immunoblotting and quantitative reverse transcription polymerase chain reaction were conducted to explore the signaling pathway by USP8 inhibition. Results： Inhibition of USP8-induced degradation of receptor tyrosine kinases including EGFR, EGFR-2 （ERBB2）, and Met leading to a suppression of ArT20 cell growth and ACTH secretion. Moreover, treatment with USP8 inhibitor markedly induced AtT20 cells apoptosis. Conclusions： Inhibition of USP8 activity could be an effective strategy for CD. It might provide a novel pharmacological approach for the treatment of CD.
Publisher
Wolters Kluwer - Medknow Publications,Medknow Publications and Media Pvt. Ltd,Lippincott Williams & Wilkins Ovid Technologies,Department of Neurosurgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China%Department of Neurosurgery, Changzheng Hospital, The Second Military Medical University, Shanghai 200003, China%Department of Neurosurgery, Shanghai Pituitary Tumor Center, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai 200040, China,Medknow Publications & Media Pvt Ltd,Wolters Kluwer
Subject
/ Adrenocorticotropic Hormone - metabolism
/ Analysis
/ Animals
/ Cell Proliferation - drug effects
/ Cell Proliferation - physiology
/ Cell Survival - drug effects
/ Endosomal Sorting Complexes Required for Transport - antagonists & inhibitors
/ Endosomal Sorting Complexes Required for Transport - metabolism
/ Enzyme Inhibitors - pharmacology
/ Enzymes
/ Epidermal growth factor receptors
/ Humans
/ Kinases
/ Mice
/ Mutation
/ Original
/ Proteins
/ Receptor, Epidermal Growth Factor - metabolism
/ Studies
/ Tumors
/ Ubiquitin Thiolesterase - antagonists & inhibitors
/ Ubiquitin Thiolesterase - metabolism
/ 促肾上腺皮质激素
/ 全基因组测序
/ 抑制剂
/ 泛素
/ 生产
/ 细胞生长
/ 表皮生长因子受体
