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Detection and Decontamination of Chronic Wasting Disease Prions during Venison Processing
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Detection and Decontamination of Chronic Wasting Disease Prions during Venison Processing
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Journal Article
Detection and Decontamination of Chronic Wasting Disease Prions during Venison Processing
2025
Overview
Prion diseases, including chronic wasting disease (CWD), are caused by prions, which are misfolded aggregates of normal cellular prion protein. Prions possess many characteristics that distinguish them from conventional pathogens, in particular, an extraordinary recalcitrance to inactivation and a propensity to avidly bind to surfaces. In middle to late stages of CWD, prions begin accumulating in cervid muscle tissues. Those features collectively create scenarios in which occupational hazards arise for workers processing venison and pose risks to consumers through direct prion exposure through ingestion and cross-contamination of food products. In this study, we demonstrate that steel and plastic surfaces used in venison processing can be directly contaminated with CWD prions and that cross-contamination of CWD-negative venison can occur from equipment that had previously been used with CWD-positive venison. We also show that several decontaminant solutions (commercial bleach and potassium peroxymonosulfate) are efficacious for prion inactivation on those same surfaces.
Publisher
U.S. National Center for Infectious Diseases,Centers for Disease Control and Prevention
Subject
/ Control
/ Decontamination (from gases, chemicals, etc.)
/ Deer
/ Detection and Decontamination of Chronic Wasting Disease Prions during Venison Processing
/ Diseases
/ Food
/ Humans
/ Identification and classification
/ Knives
/ Methods
/ Prions
/ Prions - isolation & purification
/ RT-QuIC
/ Steel
/ Testing
/ transmissible spongiform encephalopathy
/ Venison
/ Wasting Disease, Chronic - diagnosis
